40297-09-4
Chemical Structure
MDL12330A
Synonym(s): RMI12330A
- CAS No.: 40297-09-4
- Formula:C23H37ClN2
- Molecular Weight:377.01
IUPAC Name: (Z)-N-((1S,2S)-2-phenylcyclopentyl)azacyclotridec-1-en-2-amine hydrochloride
InChIKey: CKOPQUCSDBVAQG-VROPFNGYSA-N
SMILES: [H]Cl.C1(/N[C@@H]2[C@H](C3=CC=CC=C3)CCC2)=N/CCCCCCCCCCC1
Biological Activity: MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease [1][2][3].
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MDL12330A | 99.82% | MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease . | ||||||||||||||||||||
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MDL12330A (Standard) | ≥98% | MDL12330A (Standard) is the analytical standard of MDL12330A (HY-103192). MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease . | ||||||||||||||||||||
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- [1]. Okawa T, et al. Role of nucleotide cyclases in the inhibition of pregnant rat uterine contractions by the openers of potassium channels. Am J Obstet Gynecol. 2000;182(4):913-918. [Content Brief]
- [2]. Li X, et al. The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells. PLoS One. 2013;8(10):e77934. Published 2013 Oct 29. [Content Brief]
- [3]. Grupp G, et al. Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity. Br J Pharmacol. 1980 Nov;70(3):429-42. [Content Brief]
Keywords
