1. GPCR/G Protein
  2. Adenylate Cyclase
  3. NKH477

NKH477 (Synonyms: Colforsin dapropate hydrochloride)

Cat. No.: HY-103193
Handling Instructions

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

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NKH477 Chemical Structure

NKH477 Chemical Structure

CAS No. : 138605-00-2

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Description

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].

IC50 & Target

Adenylate Cyclase[1]

In Vivo

NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1].

Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g[1]
Dosage: 1, 2 or 3 mg/kg/day
Administration: Orally; daily; Days 3 and 5
Result: Prolonged lung allograft survival in a dose dependent manner.
Molecular Weight

546.09

Formula

C₂₇H₄₄ClNO₈

CAS No.

138605-00-2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NKH477
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