1. GPCR/G Protein
  2. Adenylate Cyclase
  3. NKH477

NKH477 (Synonyms: Colforsin dapropate hydrochloride)

Cat. No.: HY-103193 Purity: >99.0%
Handling Instructions

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

For research use only. We do not sell to patients.

NKH477 Chemical Structure

NKH477 Chemical Structure

CAS No. : 138605-00-2

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10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].

IC50 & Target

Adenylate Cyclase[1]

In Vivo

NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g[1]
Dosage: 1, 2 or 3 mg/kg/day
Administration: Orally; daily; Days 3 and 5
Result: Prolonged lung allograft survival in a dose dependent manner.
Molecular Weight

546.09

Formula

C₂₇H₄₄ClNO₈

CAS No.

138605-00-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (228.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8312 mL 9.1560 mL 18.3120 mL
5 mM 0.3662 mL 1.8312 mL 3.6624 mL
10 mM 0.1831 mL 0.9156 mL 1.8312 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

NKH477Colforsin dapropateNKH 477NKH-477Adenylate CyclaseAdenylyl cyclaseInhibitorinhibitorinhibit

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Product Name:
NKH477
Cat. No.:
HY-103193
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