2. GPCR/G Protein
  3. Adenylate Cyclase
  4. NKY80

NKY80 

Cat. No.: HY-103195 Purity: 99.77%
COA Handling Instructions

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.

For research use only. We do not sell to patients.

NKY80 Chemical Structure

NKY80 Chemical Structure

CAS No. : 299442-43-6

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Solution
10 mM * 1 mL in DMSO USD 133 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 133 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 121 In-stock
Estimated Time of Arrival: December 31
25 mg USD 242 In-stock
Estimated Time of Arrival: December 31
50 mg USD 418 In-stock
Estimated Time of Arrival: December 31
100 mg USD 638 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].

IC50 & Target

IC50: 8.3 µM (AC type V), 132 µM (AC type III) and 1.7 mM (AC type II)[1]
In Vitro

NKY80 (20 μM) blocks the elevations in both LVP and ventricular cAMP levels produced by the maximal concentration (10 nM)[2].
NKY80 (20 μM; 2 hours) completely blocks the increase in both cAMP content and renin release from isolated JG cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

229.23

Appearance

Solid

Formula

C12H11N3O2
CAS No.
SMILES

O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1090.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3624 mL 21.8122 mL 43.6243 mL
5 mM 0.8725 mL 4.3624 mL 8.7249 mL
10 mM 0.4362 mL 2.1812 mL 4.3624 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.77%

COA (248 KB) HNMR (183 KB) LCMS (111 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NKY80299442-43-6NKY 80NKY-80Adenylate CyclaseAdenylyl cyclaseadenylylcyclaseACtypeVisoformIIIIInon-nucleosidequinazolinoneheartlungInhibitorinhibitorinhibit

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