1. GPCR/G Protein
  2. Adenylate Cyclase
  3. NKY80

NKY80 

Cat. No.: HY-103195
Handling Instructions

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.

For research use only. We do not sell to patients.

NKY80 Chemical Structure

NKY80 Chemical Structure

CAS No. : 299442-43-6

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Description

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].

IC50 & Target

IC50: 8.3 µM (AC type V), 132 µM (AC type III) and 1.7 mM (AC type II)[1]

In Vitro

NKY80 (20 μM) blocks the elevations in both LVP and ventricular cAMP levels produced by the maximal concentration (10 nM)[2].
NKY80 (20 μM; 2 hours) completely blocks the increase in both cAMP content and renin release from isolated JG cells[3].

Molecular Weight

229.23

Formula

C₁₂H₁₁N₃O₂

CAS No.

299442-43-6

SMILES

O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

NKY80NKY 80NKY-80Adenylate CyclaseAdenylyl cyclaseadenylylcyclaseACtypeVisoformIIIIInon-nucleosidequinazolinoneheartlungInhibitorinhibitorinhibit

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