1. GPCR/G Protein
  2. Adenylate Cyclase
  3. NKY80

NKY80 

Cat. No.: HY-103195 Purity: 99.77%
Handling Instructions

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.

For research use only. We do not sell to patients.

NKY80 Chemical Structure

NKY80 Chemical Structure

CAS No. : 299442-43-6

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50 mg USD 380 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].

IC50 & Target

IC50: 8.3 µM (AC type V), 132 µM (AC type III) and 1.7 mM (AC type II)[1]

In Vitro

NKY80 (20 μM) blocks the elevations in both LVP and ventricular cAMP levels produced by the maximal concentration (10 nM)[2].
NKY80 (20 μM; 2 hours) completely blocks the increase in both cAMP content and renin release from isolated JG cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

229.23

Formula

C₁₂H₁₁N₃O₂

CAS No.

299442-43-6

SMILES

O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1090.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3624 mL 21.8122 mL 43.6243 mL
5 mM 0.8725 mL 4.3624 mL 8.7249 mL
10 mM 0.4362 mL 2.1812 mL 4.3624 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.77%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NKY80NKY 80NKY-80Adenylate CyclaseAdenylyl cyclaseadenylylcyclaseACtypeVisoformIIIIInon-nucleosidequinazolinoneheartlungInhibitorinhibitorinhibit

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NKY80
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