299442-43-6
299442-43-6
Chemical Structure
NKY80
- CAS 番号: 299442-43-6
- Formula:C12H11N3O2
- Molecular Weight:229.23
IUPAC Name: 2-amino-7-(furan-2-yl)-7,8-dihydroquinazolin-5(6H)-one
InChIKey: SOJUSNIBPPMLCC-UHFFFAOYSA-N
SMILES: O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1
Biological Activity: NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].
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NKY80 | 99.76% | NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues. | ||||||||||||||||||||
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NKY80 (Standard) | ≥98% | NKY80 (Standard) is the analytical standard of NKY80 (HY-103195). This product is intended for research and analytical applications. NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-112255J9 -
Similarity Score 0.53
HY-W107464G6PDi-1 -
Similarity Score 0.51
HY-116643SU 10603 -
Similarity Score 0.51
HY-124521Quinelorane -
Similarity Score 0.50
HY-131500SU-9055 -
Similarity Score 0.50
HY-103429Quinelorane dihydrochloride -
Similarity Score 0.50
HY-110278ADX71743 -
Similarity Score 0.49
HY-119103BPF-03246799 monohydrochloride -
Similarity Score 0.49
HY-119103PF-03246799 -
Explore the MedChemAI to find more analogs
References
- [1]. Onda T, et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibitionof adenylyl cyclase isoforms. Biol Chem. 2001 Dec 21;276(51):47785-93. [Content Brief]
- [2]. Harney JA, et al. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E155-61. [Content Brief]
