Quinelorane dihydrochloride
Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 97548-97-5
- Formula: C14H24Cl2N4
- Molecular Weight:319.27
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
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D2 Receptor |
D3 Receptor |
Quinelorane dihydrochloride (0.032, 0.32, 3.2, 5.6 mg/kg; IP) significantly and dose-dependently increases locomotor activity in the Sprague Dawley rats. There was no main effect of sex and sex interaction[1].
Quinelorane dihydrochloride significantly decreases activity in the male and female inbred FVB/NJ, BALB/cJ, BALB/cByJ, C57BL/6J, Swiss Webster, A/J, DBA/2J, 129S1/SvImJ, and 129S6/SvEvTac mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 97548-97-5
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Appearance Solid
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Molecular Weight 319.27
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Formula C14H24Cl2N4
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Color White to off-white
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SMILES
NC1=NC=C2C[C@]3([H])[C@@](CCCN3CCC)([H])CC2=N1.[H]Cl.[H]Cl
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Synonyms
LY163502
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (313.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ying Qu, et al. Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies. Pharmacol Biochem Behav. 2008 Oct;90(4):686-90. [Content Brief]
[2]. Morgane Thomsen, et al. Psychomotor stimulation by dopamine D₁-like but not D₂-like agonists in most mouse strains. Exp Clin Psychopharmacol. 2011 Oct;19(5):342-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1321 mL | 15.6607 mL | 31.3215 mL | 78.3036 mL |
| 5 mM | 0.6264 mL | 3.1321 mL | 6.2643 mL | 15.6607 mL | |
| 10 mM | 0.3132 mL | 1.5661 mL | 3.1321 mL | 7.8304 mL | |
| 15 mM | 0.2088 mL | 1.0440 mL | 2.0881 mL | 5.2202 mL | |
| 20 mM | 0.1566 mL | 0.7830 mL | 1.5661 mL | 3.9152 mL | |
| 25 mM | 0.1253 mL | 0.6264 mL | 1.2529 mL | 3.1321 mL | |
| 30 mM | 0.1044 mL | 0.5220 mL | 1.0440 mL | 2.6101 mL | |
| 40 mM | 0.0783 mL | 0.3915 mL | 0.7830 mL | 1.9576 mL | |
| 50 mM | 0.0626 mL | 0.3132 mL | 0.6264 mL | 1.5661 mL | |
| 60 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3051 mL | |
| 80 mM | 0.0392 mL | 0.1958 mL | 0.3915 mL | 0.9788 mL | |
| 100 mM | 0.0313 mL | 0.1566 mL | 0.3132 mL | 0.7830 mL |
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