2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Quinelorane dihydrochloride

Quinelorane dihydrochloride  (Synonyms: LY163502)

Cat. No.: HY-103429 Purity: ≥99.0%
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Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research.

For research use only. We do not sell to patients.

Quinelorane dihydrochloride Chemical Structure

Quinelorane dihydrochloride Chemical Structure

CAS No. : 97548-97-5

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Based on 1 publication(s) in Google Scholar

Quinelorane dihydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research[1][2].

IC50 & Target[1][2]

D2 Receptor

 

D3 Receptor

 

In Vivo

Quinelorane dihydrochloride (LY163502; 0.003, 0.01 mg/kg; s.c.) reduces GABA efflux, with significant effects with 0.01 but not 0.003 mg/kg in male Wistar rats (300 g)[1].
Quinelorane dihydrochloride (0.032, 0.32, 3.2, 5.6 mg/kg; IP) significantly and dose-dependently increases locomotor activity in the Sprague Dawley rats. There was no main effect of sex and sex interaction[1].
Quinelorane dihydrochloride significantly decreases activity in the male and female inbred FVB/NJ, BALB/cJ, BALB/cByJ, C57BL/6J, Swiss Webster, A/J, DBA/2J, 129S1/SvImJ, and 129S6/SvEvTac mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

319.27

Formula

C14H24Cl2N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=C2C[C@]3([H])[C@@](CCCN3CCC)([H])CC2=N1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (313.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1321 mL 15.6607 mL 31.3215 mL
5 mM 0.6264 mL 3.1321 mL 6.2643 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1321 mL 15.6607 mL 31.3215 mL 78.3036 mL
5 mM 0.6264 mL 3.1321 mL 6.2643 mL 15.6607 mL
10 mM 0.3132 mL 1.5661 mL 3.1321 mL 7.8304 mL
15 mM 0.2088 mL 1.0440 mL 2.0881 mL 5.2202 mL
20 mM 0.1566 mL 0.7830 mL 1.5661 mL 3.9152 mL
25 mM 0.1253 mL 0.6264 mL 1.2529 mL 3.1321 mL
30 mM 0.1044 mL 0.5220 mL 1.0440 mL 2.6101 mL
40 mM 0.0783 mL 0.3915 mL 0.7830 mL 1.9576 mL
50 mM 0.0626 mL 0.3132 mL 0.6264 mL 1.5661 mL
60 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3051 mL
80 mM 0.0392 mL 0.1958 mL 0.3915 mL 0.9788 mL
100 mM 0.0313 mL 0.1566 mL 0.3132 mL 0.7830 mL
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Quinelorane dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinelorane97548-97-5LY163502LY 163502LY-163502Dopamine ReceptorGABAlocomotorInhibitorinhibitorinhibit

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