64564-03-0
64564-03-0
Chemical Structure
Guanylyl imidodiphosphate lithium
Synonym(s): Gpp(NH)p lithium
- CAS No.: 64564-03-0
- Formula:C10H13Li4N6O13P3
- Molecular Weight:545.93
InChIKey: NUKFMILQQVRELO-ZVQJTLEUSA-J
SMILES: O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](N[P](O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)([H])N2C(NC(N)=NC3=O)=C3N=C2
Biological Activity: Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Guanylyl imidodiphosphate lithium | 99.86% | Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-137677BGTPγS tetralithium -
Similarity Score 0.79
HY-128933AMP-PNP tetralithium -
Similarity Score 0.78
HY-137683BGuanosine 5'-O-2-thiodiphosphate trilithium -
Similarity Score 0.73
HY-150172AInosine 5'-triphosphate lithium salt -
Similarity Score 0.72
HY-115736BXanthosine-5'-triphosphate lithium -
Similarity Score 0.72
HY-12695Guanosine triphosphate trisodium -
Similarity Score 0.71
HY-137677GTP-γ-S -
Similarity Score 0.71
HY-1556005′-Guanylyl methylenediphosphonate sodium -
Similarity Score 0.70
HY-137674BisoGTP lithium -
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References
- [1]. Abou-Issa H, et al. Modulation of follicle-stimulating hormone-sensitive rat testicular adenylate cyclase activity by guanyl nucleotides. Endocrinology. 1979;104(1):189-193. [Content Brief]
- [2]. Ohtsuki K, et al. Characterization of nucleoside-diphosphate kinase-associated guanine nucleotide-binding proteins from HeLa S3 cells. Biochim Biophys Acta. 1986;882(3):322-330. [Content Brief]
- [3]. Terry BJ, et al. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate. J Biol Chem. 1980;255(21):10532-10536. [Content Brief]
