Sp-8-Br-cAMPS
Sp-8-Br-cAMPS is an analog of cAMP(HY-B1511). Sp-8-Br-cAMPS is an agonist for cAMP, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve.
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- No. CAS: 127634-20-2
- Fòrmula: C10H11BrN5O5PS
- Peso molecular:424.17
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-137622
Sp-cGMPSPKG Activator -
HY-103322
6-Bnz-cAMP sodium saltPKA Activator -
HY-123396
8-Chloro-cAMPcAMP Analogue -
HY-100530
Rp-cAMPS triethylammonium saltPKA I/II Antagonist -
HY-107544
8-pCPT-2'-O-Me-cAMP-AMAMP Analogue -
HY-100530A
Rp-cAMPSPKA I/II Antagonist -
HY-137633
Sp-8-Br-PET-cGMPSPKG Agonist -
HY-120994B
Sp-8-CPT-cAMPSPKA Activator -
HY-137638
Sp-5,6-DCl-cBIMPScAMP-PK Activator -
HY-137640B
Rp-8-Br-cAMPSPKA Inhibitor -
HY-131421
8-PIP-cAMPProtein Kinase Activator -
HY-120994A
Rp-8-CPT-cAMPSPKA Antagonist
Actividad biológica
Descripciòn
Chemical Information
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No. CAS 127634-20-2
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Peso molecular 424.17
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Fòrmula C10H11BrN5O5PS
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SMILES
NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S)=O)O3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureza y Documentación
Referencias
[1]. Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169(2):802-8. [Content Brief]
[2]. Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83(2):150-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sp-8-Br-cAMPS Related Classifications
HY-137640 Related Classifications
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