127634-20-2
Chemical Structure
Sp-8-Br-cAMPS
- CAS No.: 127634-20-2
- Formula:C10H11BrN5O5PS
- Molecular Weight:424.17
IUPAC Name: (2S,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxy-2-mercaptotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide
InChIKey: RBORURQQJIQWBS-FHIGPPGSSA-N
SMILES: NC1=NC=NC2=C1N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S)=O)O3
Biological Activity: Sp-8-Br-cAMPS is an analog of cAMP(HY-B1511). Sp-8-Br-cAMPS is an agonist for cAMP, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve[1][2].
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Sp-8-Br-cAMPS | Sp-8-Br-cAMPS is an analog of cAMP(HY-B1511). Sp-8-Br-cAMPS is an agonist for cAMP, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve. | |||||||||||||||||||||
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- [1]. Aandahl EM, et al., Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I. J Immunol. 2002 Jul 15;169(2):802-8. [Content Brief]
- [2]. Brooks CL, et al., Protein kinase A affects Galleria mellonella (Insecta: Lepidoptera) larval haemocyte non-self responses. Immunol Cell Biol. 2005 Apr;83(2):150-9. [Content Brief]
Keywords
