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2-Chloroadenosine 

Cat. No.: HY-W008344 Purity: 99.79%
Handling Instructions

2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes.

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2-Chloroadenosine Chemical Structure

2-Chloroadenosine Chemical Structure

CAS No. : 146-77-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 89 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].

Molecular Weight

301.69

Formula

C₁₀H₁₂ClN₅O₄

CAS No.

146-77-0

SMILES

ClC1=NC(N)=C(N=CN2[[email protected]@]3([H])[[email protected]@](O)([H])[[email protected]@](O)([H])[[email protected]@](O3)([H])CO)C2=N1

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (331.47 mM; Need ultrasonic)

H2O : 33.33 mg/mL (110.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3147 mL 16.5733 mL 33.1466 mL
5 mM 0.6629 mL 3.3147 mL 6.6293 mL
10 mM 0.3315 mL 1.6573 mL 3.3147 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.29 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 18.75 mg/mL (62.15 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.79%

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Keywords:

2-ChloroadenosineOthersanalogueischaemiccelllosstransportedpermeanthumanerythrocytes,uridineinflux,nitrobenzylthioinosineInhibitorinhibitorinhibit

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Product Name:
2-Chloroadenosine
Cat. No.:
HY-W008344
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