Search Result
Results for "
permeant
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D1078
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Reactive Oxygen Species
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Others
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5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture
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- HY-W008344
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Nucleoside Antimetabolite/Analog
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Others
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2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes .
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- HY-117359
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PAI-1
Apoptosis
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Cancer
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UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis .
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- HY-D1748
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Fluorescent Dye
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Others
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Rhodamine B hexyl ester perchlorate is a cell-permeant, orange-fluorescent dye for mitochondria.
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- HY-P10167
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Phosphatase
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Others
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11R-CaN-AID is a potent and cell permeant inhibitor of calcineurin .
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- HY-15465B
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CaMK
Autophagy
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Cancer
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KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
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- HY-153056
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Others
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Others
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BNN3 is a caged nitric oxide (NO) donor. BNN3 is membrane-permeant and incorporated in the lipid membrane .
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- HY-141510A
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ITPP hexa-triethylamine
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Others
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Others
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myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine, a inositol tripyrophosphate (ITPP) salt, is a membrane permeant allosteric effector of haemoglobin .
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- HY-110256
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- HY-P1369
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Dynamin
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Neurological Disease
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DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .
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- HY-D1758
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Fluorescent Dye
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Others
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Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
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- HY-D1759
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Fluorescent Dye
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Others
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Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
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- HY-P1369A
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Dynamin
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Neurological Disease
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DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis .
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- HY-103306
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Others
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Neurological Disease
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Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
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- HY-D1176
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Fluorescent Dye
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Others
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Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .
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- HY-D1760
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Sodium-binding benzofuran isophthalate
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Fluorescent Dye
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Others
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SBFI is a membrane-permeant, fluorescent Na + indicator dye. SBFI is excited at 340 nm and the fluorophore emission is collected at 450 nm . SBFI selective for Na + over K + with Kd values of 20 and 120 mM for these ions, respectively. .
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- HY-D1416
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Fluorescent Dye
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Others
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HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .
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- HY-103316A
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Ned 19
2 Publications Verification
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Calcium Channel
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Cancer
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Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca 2+ signaling, with an IC50 of 65 nM . Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice .
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- HY-P1986
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Caspase
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Cancer
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Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
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- HY-129677
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Others
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Others
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ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker .
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- HY-D1768
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Fluorescent Dye
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Others
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Fluo-4FF AM is a cell-permeant fluorescent calcium indicator. Fluo-4FF is an analog of Fluo-4 with a lower affinity for calcium, which is suitable for investigation of relatively high level of intracellular calcium.
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- HY-114227
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DNA Stain
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Inflammation/Immunology
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Hexidium iodide, a fluorescent nucleic binding acid stain (excitation/emission ~ 518/600 nm), permeants to mammalian cells and selectively stains almost all gram-positive bacteria. Hexidium iodide can bind to the DNA of all bacteria after permeabilization by EDTA .
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- HY-D1643
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Biochemical Assay Reagents
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Others
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5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca 2+. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .
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- HY-121764
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Melanocortin Receptor
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Metabolic Disease
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MPCI is a cell-permeant MC4R-selective ligand with pharmacological chaperone activity. MPCI is a MC4R antagonist with a Ki value of 0.218 μM on HEK293 cells expressing hMC4R. MPCI can be used for the research of MC4R-deficient obesity .
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- HY-145695
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Cholinesterase (ChE)
Monoamine Oxidase
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Neurological Disease
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Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC50=550 nM) and MAO B (IC50=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability .
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- HY-130412
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Fluorescent Dye
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Others
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FlAsH-EDT2 is a protein labeling reagent. FlAsH-EDT2 also is a membrane-permeant fluorogenic biarsenicals. FlAsH-EDT2 binds to CCXXCC motifs and non-specifically to endogenous cysteine-rich proteins. FlAsH-EDT2 can be useful only for labeling those recombinant proteins that express at a very high level .
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- HY-D1742
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Fluorescent Dye
DNA Stain
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Others
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DRAQ5 is a novel cell permeant and far red-fluorescing DNA probe. DRAQ5 excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DRAQ5 fluorescence reflects cellular DNA content. DRAQ5 can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .
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- HY-112210
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Shld1
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FKBP
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Others
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Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) .
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- HY-P3412
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MAPKAPK2 (MK2)
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Inflammation/Immunology
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MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
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- HY-D1746
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EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
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Biochemical Assay Reagents
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Others
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EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
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- HY-Z0816
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Calcium Channel
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Others
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Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders .
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- HY-108611
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AACOCF3
2 Publications Verification
Arachidonyl trifluoromethyl ketone
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Phospholipase
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Cardiovascular Disease
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AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
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- HY-18971
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TG4-155
1 Publications Verification
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TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM . TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 . TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor .
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- HY-P2307A
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iGluR
NO Synthase
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Neurological Disease
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Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
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- HY-P2307
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iGluR
NO Synthase
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Neurological Disease
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Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
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| Cat. No. |
Product Name |
Type |
-
- HY-D1748
-
|
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Fluorescent Dyes/Probes
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Rhodamine B hexyl ester perchlorate is a cell-permeant, orange-fluorescent dye for mitochondria.
|
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- HY-D1758
-
|
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Fluorescent Dyes/Probes
|
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Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
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- HY-D1759
-
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Fluorescent Dyes/Probes
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Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
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- HY-D1176
-
|
|
Fluorescent Dyes/Probes
|
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Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .
|
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- HY-D1760
-
|
Sodium-binding benzofuran isophthalate
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Fluorescent Dyes/Probes
|
|
SBFI is a membrane-permeant, fluorescent Na + indicator dye. SBFI is excited at 340 nm and the fluorophore emission is collected at 450 nm . SBFI selective for Na + over K + with Kd values of 20 and 120 mM for these ions, respectively. .
|
-
- HY-D1416
-
|
|
Fluorescent Dyes/Probes
|
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HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .
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- HY-P1986
-
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Fluorescent Dyes/Probes
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Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
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- HY-D1768
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Fluorescent Dyes/Probes
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Fluo-4FF AM is a cell-permeant fluorescent calcium indicator. Fluo-4FF is an analog of Fluo-4 with a lower affinity for calcium, which is suitable for investigation of relatively high level of intracellular calcium.
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- HY-D1742
-
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Fluorescent Dyes/Probes
|
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DRAQ5 is a novel cell permeant and far red-fluorescing DNA probe. DRAQ5 excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DRAQ5 fluorescence reflects cellular DNA content. DRAQ5 can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .
|
-
- HY-D1746
-
|
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
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Fluorescent Dyes/Probes
|
|
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1369
-
|
|
Dynamin
|
Neurological Disease
|
|
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .
|
-
- HY-P1986
-
|
|
Caspase
|
Cancer
|
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Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
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- HY-P3412
-
|
|
MAPKAPK2 (MK2)
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Inflammation/Immunology
|
|
MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
|
-
- HY-P10167
-
|
|
Phosphatase
|
Others
|
|
11R-CaN-AID is a potent and cell permeant inhibitor of calcineurin .
|
-
- HY-P1369A
-
|
|
Dynamin
|
Neurological Disease
|
|
DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis .
|
-
- HY-P2307A
-
|
|
iGluR
NO Synthase
|
Neurological Disease
|
|
Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
|
-
- HY-P2307
-
|
|
iGluR
NO Synthase
|
Neurological Disease
|
|
Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-131442
-
|
Alkyne tyramide; Alk-Ph
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Labeling and Fluorescence Imaging
Alkynes
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Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins . Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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