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  4. myo-Inositol trispyrophosphate hexa-triethylamine

myo-Inositol trispyrophosphate hexa-triethylamine  (Synonyms: ITPP hexa-triethylamine)

製品番号: HY-141510A 純度: 98.0%
COA 取扱説明書 Technical Support

myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate hexa-triethylamine is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate hexa-triethylamine enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate hexa-triethylamine can be used in the study of cardiovascular disease and cancer.

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myo-Inositol trispyrophosphate hexa-triethylamine

myo-Inositol trispyrophosphate hexa-triethylamine 構造式

CAS 番号 : 851086-77-6

容量 価格（税別） 在庫状況 数量
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 427 在庫あり
Solution
10 mM * 1 mL in Water USD 427 在庫あり
Oil
5 mg $180 在庫あり
10 mg $320 在庫あり
25 mg $680 在庫あり
50 mg $1150 在庫あり
100 mg $1980 在庫あり
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myo-Inositol trispyrophosphate hexa-triethylamine 関連抗体

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製品説明

myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate hexa-triethylamine is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate hexa-triethylamine enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate hexa-triethylamine can be used in the study of cardiovascular disease and cancer[1][2][3].

体外実験

Non-salt dose:
myo-Inositol trispyrophosphate (78 mM; 1 h) significantly reduces hypoxia-induced HIF-1α expression in red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

myo-Inositol trispyrophosphate hexa-triethylamine 関連抗体
体内実験

Non-salt dose:
myo-Inositol trispyrophosphate (1.5 g/kg; intraperitoneal injection; twice a week for 4 weeks) has a protective effect in rat model of myocardial infarction[1].
myo-Inositol trispyrophosphate (1.5 g/kg; intravenous injection; once a week for 11 weeks) has antitumor activity in a rat model of pancreatic cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (280-320 g) with myocardial infarction[1]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intraperitoneal injection (i.p.); twice a week for 4 weeks
Result: Essentially halted the increase of LV dilation and significantly reduced impairment of LV ejection fraction, while it had no effect on sham-operated rats.
Animal Model: DSL-6A/C1 tumors treated immunocompetent male Lewis rats[2]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intravenous injection (i.v.); once a week for 11 weeks
Result: Significantly extended the survival time of rats.
Basically did not cause liver metastasis and primary tumor growth was restricted to 2 cm3.
Restored the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors.
分子量

1213.13

分子式

C6H12O21P6.6C6H15N
CAS 番号
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=P1(O[C@]2([H])[C@@]3([H])[C@@](OP(O)(OP(O)(O3)=O)=O)([H])[C@]4([H])[C@@](OP(O)(OP(O)(O4)=O)=O)([H])[C@@]2([H])OP(O)(O1)=O)O.CCN(CC)CC.[6]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

H2O : 125 mg/mL (103.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8243 mL 4.1216 mL 8.2431 mL
5 mM 0.1649 mL 0.8243 mL 1.6486 mL
10 mM 0.0824 mL 0.4122 mL 0.8243 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8243 mL 4.1216 mL 8.2431 mL 20.6078 mL
5 mM 0.1649 mL 0.8243 mL 1.6486 mL 4.1216 mL
10 mM 0.0824 mL 0.4122 mL 0.8243 mL 2.0608 mL
15 mM 0.0550 mL 0.2748 mL 0.5495 mL 1.3739 mL
20 mM 0.0412 mL 0.2061 mL 0.4122 mL 1.0304 mL
25 mM 0.0330 mL 0.1649 mL 0.3297 mL 0.8243 mL
30 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6869 mL
40 mM 0.0206 mL 0.1030 mL 0.2061 mL 0.5152 mL
50 mM 0.0165 mL 0.0824 mL 0.1649 mL 0.4122 mL
60 mM 0.0137 mL 0.0687 mL 0.1374 mL 0.3435 mL
80 mM 0.0103 mL 0.0515 mL 0.1030 mL 0.2576 mL
100 mM 0.0082 mL 0.0412 mL 0.0824 mL 0.2061 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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myo-Inositol trispyrophosphate hexa-triethylamine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

myo-Inositol trispyrophosphate hexa-triethylamine851086-77-6ITPP hexa-triethylamineBiochemical Assay ReagentsHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHred blood cellsmyocardial infarction modelpancreatic cancer modelInhibitorinhibitorinhibit

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myo-Inositol trispyrophosphate hexa-triethylamine
製品番号:
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