myo-Inositol trispyrophosphate hexasodium
Based on 1 Customer Validation
myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer.
For research use only. We do not sell to patients.
- Purity : 95.0%
- CAS No.: 23103-35-7
- Formula: C6H6Na6O21P6
- Molecular Weight:737.88
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
In Vivo
myo-Inositol trispyrophosphate (1.5 g/kg; intraperitoneal injection; twice a week for 4 weeks) has a protective effect in rat model of myocardial infarction[1].
myo-Inositol trispyrophosphate (1.5 g/kg; intravenous injection; once a week for 11 weeks) has antitumor activity in a rat model of pancreatic cancer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (280-320 g) with myocardial infarction[1]
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Dosage:1.5 g/kg (Non-salt dose)
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Administration:Intraperitoneal injection (i.p.); twice a week for 4 weeks
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Result:Essentially halted the increase of LV dilation and significantly reduced impairment of LV ejection fraction, while it had no effect on sham-operated rats.
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Animal Model:DSL-6A/C1 tumors treated immunocompetent male Lewis rats[2]
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Dosage:1.5 g/kg (Non-salt dose)
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Administration:Intravenous injection (i.v.); once a week for 11 weeks
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Result:Significantly extended the survival time of rats.
Basically did not cause liver metastasis and primary tumor growth was restricted to 2 cm3.
Restored the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors.
Chemical Information
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CAS No. 23103-35-7
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Appearance Solid
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Molecular Weight 737.88
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Formula C6H6Na6O21P6
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Color White to off-white
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SMILES
O=P1(O[C@]2([H])[C@@]3([H])[C@@](OP(OP(O3)(O[Na])=O)(O[Na])=O)([H])[C@]4([H])[C@@](OP(OP(O4)(O[Na])=O)(O[Na])=O)([H])[C@@]2([H])OP(O1)(O[Na])=O)O[Na]
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Synonyms
ITPP hexasodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
H2O : 25 mg/mL (33.88 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (290 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Oknińska M, et al. Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells. J Cell Mol Med. 2020 Feb;24(3):2272-2283. [Content Brief]
[2]. Raykov Z, et al. Myo-inositol trispyrophosphate-mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy. Int J Cancer. 2014 Jun 1;134(11):2572-82. [Content Brief]
[3]. Fylaktakidou KC, et al. Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1605-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3552 mL | 6.7762 mL | 13.5523 mL | 33.8808 mL |
| 5 mM | 0.2710 mL | 1.3552 mL | 2.7105 mL | 6.7762 mL | |
| 10 mM | 0.1355 mL | 0.6776 mL | 1.3552 mL | 3.3881 mL | |
| 15 mM | 0.0903 mL | 0.4517 mL | 0.9035 mL | 2.2587 mL | |
| 20 mM | 0.0678 mL | 0.3388 mL | 0.6776 mL | 1.6940 mL | |
| 25 mM | 0.0542 mL | 0.2710 mL | 0.5421 mL | 1.3552 mL | |
| 30 mM | 0.0452 mL | 0.2259 mL | 0.4517 mL | 1.1294 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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