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myo-Inositol trispyrophosphate hexasodium (Synonyms: ITPP hexasodium)

Cat. No.: HY-141510
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myo-Inositol trispyrophosphate (ITPP) hexasodium, a modifier of haemoglobin, is an allosteric effector that reduces the oxygen‐binding affinity of haemoglobin and facilitates the release of oxygen by red blood cells. myo-Inositol trispyrophosphate can reverse hypoxia, control tumor growth and improve chemotherapy response.

For research use only. We do not sell to patients.

myo-Inositol trispyrophosphate hexasodium Chemical Structure

myo-Inositol trispyrophosphate hexasodium Chemical Structure

CAS No. : 23103-35-7

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Description

myo-Inositol trispyrophosphate (ITPP) hexasodium, a modifier of haemoglobin, is an allosteric effector that reduces the oxygen‐binding affinity of haemoglobin and facilitates the release of oxygen by red blood cells. myo-Inositol trispyrophosphate can reverse hypoxia, control tumor growth and improve chemotherapy response[1][2][3].

In Vitro

myo-Inositol trispyrophosphate hexasodium (10 mmol/L; 2 hours) significantly inhibits OCR in all six cell lines (FSaII, SiHa, MDA‐MB‐231, NT2, 9L‐glioma and rhabdomyosarcoma) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

myo-Inositol trispyrophosphate hexasodium (2 g/kg weekly; IP; 7weeks) sustains its significant effect on life prolongation[1].
myo-Inositol trispyrophosphate hexasodium (1.5 g/kg weekly; IV; for 8 weeks) remains metastasis-free on pancreatic carcinomas in immunocompetent male Lewis rats weighing 120-150 g with DSL-6A/C1 cells. myo-Inositol trispyrophosphate hexasodium restores the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors[1].
myo-Inositol trispyrophosphate hexasodium (2 g/kg; once daily for 2 days) shows the most elevated tumour oxygenation at 2 hours in four mouse tumour models (mouse fibrosarcoma FSaII implanted in C3H mice, mouse mammary tumour NT2 in FVb/Nrj mice, human breast cancer MDA‐MB‐231 in NMRI nude mice and human cervix squamous cell carcinoma SiHa in NMRI nude mice) and two rat tumour models (rat 9L‐glioma in Fischer F344 rats and rat rhabdomyosarcoma in WAG/Rij rats)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (20 g) with MiaPaCa-2 or DSL-6A/C1 cells[1]
Dosage: 2 g/kg (weekly)
Administration: IP; weekly; 7weeks
Result: Sustained its significant effect on life prolongation.
Molecular Weight

737.88

Formula

C₆H₆Na₆O₂₁P₆

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myo-Inositol trispyrophosphate hexasodium
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HY-141510
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