1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Immunology/Inflammation
  2. iGluR
    NO Synthase
  3. Tat-NR2Baa TFA

Tat-NR2Baa TFA 

Cat. No.: HY-P2307A
Handling Instructions

Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.

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Tat-NR2Baa TFA Chemical Structure

Tat-NR2Baa TFA Chemical Structure

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Description

Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95[1].

In Vitro

Tat-NR2BAA TFA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue[1].
Tat-NR2BAA TFA (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell.But Tat-NR2BAA TFA has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117)[1].
Tat-NR2BAA TFA (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons[2].

Molecular Weight

2588.85

Formula

C₁₀₅H₁₈₅F₃N₄₂O₃₁

Sequence

{Tyr}{Gly}{Arg}{Lys}{Lys}{Arg}{Arg}{Gln}{Arg}{Arg}{Arg}{Lys}{Leu}{Ser}{Ser}{Ile}{Glu}{Ala}{Asp}{Ala}

Sequence Shortening

YGRKKRRQRRRKLSSIEADA

SMILES

[YGRKKRRQRRRKLSSIEADA (TFA salt)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Tat-NR2BaaiGluRNO SynthaseIonotropic glutamate receptorsNitric oxide synthasesNOSdesensitizationexcitotoxicityhippocampusNMDA receptorPSD-95striatumInhibitorinhibitorinhibit

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Tat-NR2Baa TFA
Cat. No.:
HY-P2307A
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