1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Immunology/Inflammation
  2. iGluR
    NO Synthase
  3. Tat-NR2Baa

Tat-NR2Baa 

Cat. No.: HY-P2307 Purity: 96.26%
Handling Instructions

Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Tat-NR2Baa Chemical Structure

Tat-NR2Baa Chemical Structure

CAS No. : 847829-41-8

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1 mg USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
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10 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95[1][2].

In Vitro

Tat-NR2BAA (125 ng; 20 mins) does not effects interactions between PSD-95 and NR2B subunits. In contrast, coimmunoprecipitation of PSD-95 with NR2B subunits is markedly decreased in rats pretreated with the disrupting peptide Tat-NR2B9c in lumbar dorsal horn tissue[1].
Tat-NR2Baa (125 ng or 1.25 μg; 20 minutes before collection of lumbar dorsal horn tissue) is the control group of Tat-NR2B9c. Tat-NR2B9c produces a significant and robust reduction of postdischarge, indicating the hyperexcitability of the cell. But Tat-NR2Baa has no effects, even at a dose 100× greater than the active peptide Tat-NR2B9c (HY-P0117)[1].
Tat-NR2Baa (1 μM; pre-treatment 1 hour) is the control group in the Co-IP assay. Tat-NR2B9c (1 μM) disrupts NR2B/PSD95 interaction, and the coupling of NR2B to PSD-95 is more sensitive than NR2A/PSD95 to disruption in hippocampal neurons[2].

Molecular Weight

2474.83

Formula

C₁₀₃H₁₈₄N₄₂O₂₉

CAS No.

847829-41-8

Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ala-Asp-Ala

Sequence Shortening

YGRKKRRQRRRKLSSIEADA

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Tat-NR2BaaiGluRNO SynthaseIonotropic glutamate receptorsNitric oxide synthasesNOSdesensitizationexcitotoxicityhippocampusNMDA receptorPSD-95striatumInhibitorinhibitorinhibit

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Tat-NR2Baa
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