ORC-13661 hydrochloride
ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.
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- CAS No.: 1979935-34-6
- Formule: C18H20Cl2N4O2S
- Masse moléculaire:427.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
ORC-13661 (0.10-8.3 μM; wild type *AB Zebrafish hair cells) hydrochloride protects zebrafish hair cells from multiple aminoglycosides (AGs)[1].
ORC-13661 (0.10-20 μM) hydrochloride protects zebrafish lateral line hair cells and mammalian hair cells from Cisplatin (HY-17394)[1].
ORC-13661 (0.3 and 3 μM) hydrochloride is a reversible blocker of the MET channel of auditory hair cells. ORC-13661 hydrochloride blocks OHC MET currents. ORC-13661 hydrochloride MET channel block is voltage dependent and permeant[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Fischer 344 rat[1]
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Dosage:0.2, 1, and 5 mg/kg
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Administration:Oral administration; daily, for 10 days
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Result:Protected hearing in mammals from different AG antibiotics.
Chemical Information
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CAS No. 1979935-34-6
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Masse moléculaire 427.35
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Formule C18H20Cl2N4O2S
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SMILES
NC(C1=C(NC(NC2=CC=C(C=C2)Cl)=O)SC3=C1[C@](CC4)([H])N(C)[C@]4([H])C3)=O.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)