ORC-13661 hydrochloride
ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.
For research use only. We do not sell to patients.
- CAS No.: 1979935-34-6
- Formula: C18H20Cl2N4O2S
- Molecular Weight:427.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
ORC-13661 (0.10-8.3 μM; wild type *AB Zebrafish hair cells) hydrochloride protects zebrafish hair cells from multiple aminoglycosides (AGs)[1].
ORC-13661 (0.10-20 μM) hydrochloride protects zebrafish lateral line hair cells and mammalian hair cells from Cisplatin (HY-17394)[1].
ORC-13661 (0.3 and 3 μM) hydrochloride is a reversible blocker of the MET channel of auditory hair cells. ORC-13661 hydrochloride blocks OHC MET currents. ORC-13661 hydrochloride MET channel block is voltage dependent and permeant[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Fischer 344 rat[1]
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Dosage:0.2, 1, and 5 mg/kg
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Administration:Oral administration; daily, for 10 days
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Result:Protected hearing in mammals from different AG antibiotics.
Chemical Information
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CAS No. 1979935-34-6
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Molecular Weight 427.35
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Formula C18H20Cl2N4O2S
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SMILES
NC(C1=C(NC(NC2=CC=C(C=C2)Cl)=O)SC3=C1[C@](CC4)([H])N(C)[C@]4([H])C3)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)