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  3. ORC-13661 hydrochloride

ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.

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ORC-13661 hydrochloride Chemical Structure

ORC-13661 hydrochloride Chemical Structure

CAS No. : 1589571-77-6

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Description

ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker[1].

In Vitro

ORC-13661 (0.10-8.3 μM; wild type *AB Zebrafish hair cells) hydrochloride protects zebrafish hair cells from multiple aminoglycosides (AGs)[1].
ORC-13661 (0.10-20 μM) hydrochloride protects zebrafish lateral line hair cells and mammalian hair cells from Cisplatin (HY-17394)[1].
ORC-13661 (0.3 and 3 μM) hydrochloride is a reversible blocker of the MET channel of auditory hair cells. ORC-13661 hydrochloride blocks OHC MET currents. ORC-13661 hydrochloride MET channel block is voltage dependent and permeant[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ORC-13661 (0.2-5 mg/kg; p.o.; daily, for 10 d) hydrochloride protects hearing from amikacin in rats in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer 344 rat[1]
Dosage: 0.2, 1, and 5 mg/kg
Administration: Oral administration; daily, for 10 days
Result: Protected hearing in mammals from different AG antibiotics.
Molecular Weight

427.35

Formula

C18H20Cl2N4O2S

CAS No.
SMILES

NC(C(C(C[C@]1([H])CC2)=C(S3)[C@]2([H])N1C)=C3NC(NC(C=C4)=CC=C4Cl)=O)=O.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ORC-13661 hydrochloride Related Classifications

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Product Name:
ORC-13661 hydrochloride
Cat. No.:
HY-129677
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