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Cat. No.: HY-129677

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ORC-13661 hydrochloride

ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.

For research use only. We do not sell to patients.

CAS No.: 1979935-34-6
Formula: C₁₈H₂₀Cl₂N₄O₂S
Molecular Weight:427.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

ORC-13661 hydrochloride Chemical Structure

CAS No.: 1979935-34-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TRP Channel Isoforms :

In Vitro

ORC-13661 (0.10-8.3 μM; wild type *AB Zebrafish hair cells) hydrochloride protects zebrafish hair cells from multiple aminoglycosides (AGs)^[1].
ORC-13661 (0.10-20 μM) hydrochloride protects zebrafish lateral line hair cells and mammalian hair cells from Cisplatin (HY-17394)^[1].
ORC-13661 (0.3 and 3 μM) hydrochloride is a reversible blocker of the MET channel of auditory hair cells. ORC-13661 hydrochloride blocks OHC MET currents. ORC-13661 hydrochloride MET channel block is voltage dependent and permeant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ORC-13661 (0.2-5 mg/kg; p.o.; daily, for 10 d) hydrochloride protects hearing from amikacin in rats in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Fischer 344 rat^[1]
Dosage:

0.2, 1, and 5 mg/kg
Administration:

Oral administration; daily, for 10 days
Result:

Protected hearing in mammals from different AG antibiotics.

Chemical Information

CAS No. 1979935-34-6
Molecular Weight 427.35
Formula C₁₈H₂₀Cl₂N₄O₂S
SMILES

NC(C1=C(NC(NC2=CC=C(C=C2)Cl)=O)SC3=C1[C@](CC4)([H])N(C)[C@]4([H])C3)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kitcher SR, et, al. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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ORC-13661 hydrochloride

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ORC-13661 hydrochloride Related Classifications

HY-129677 Related Classifications