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Cat. No.: HY-145695

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Dual AChE-MAO B-IN-1

Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC₅₀=550 nM) and MAO B (IC₅₀=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability.

For research use only. We do not sell to patients.

CAS No.: 3037140-66-9
Formula: C₂₃H₂₅F₂NO₄
Molecular Weight:417.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Dual AChE-MAO B-IN-1 Chemical Structure

CAS No.: 3037140-66-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

AChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

Dual AChE-MAO B-IN-1 (compound 15) (1-100 μM) has no significant effect on the viability of human neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells even at concentration up to 100 μM^[1].
Dual AChE-MAO B-IN-1 (compound 15) (0.1-5 μM, 24 h) can reduce neuronal damage produced by Aβ1-42 and H₂O₂ and completely shut down N-methyl-d-aspartate (NMDA) toxicity in neuroblastoma cultures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3037140-66-9
Molecular Weight 417.45
Formula C₂₃H₂₅F₂NO₄
SMILES

OCC(C(C=C1)=C(O2)C=C1OCC3=CC=C(CN(C)CCCC(F)F)C=C3)=CC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rullo M, et al. Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies. J Med Chem. 2022;65(5):3962-3977. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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