Dual AChE-MAO B-IN-1
Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC50=550 nM) and MAO B (IC50=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability.
For research use only. We do not sell to patients.
- CAS No.: 3037140-66-9
- Formula: C23H25F2NO4
- Molecular Weight:417.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE |
Dual AChE-MAO B-IN-1 (compound 15) (1-100 μM) has no significant effect on the viability of human neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells even at concentration up to 100 μM[1].
Dual AChE-MAO B-IN-1 (compound 15) (0.1-5 μM, 24 h) can reduce neuronal damage produced by Aβ1-42 and H2O2 and completely shut down N-methyl-d-aspartate (NMDA) toxicity in neuroblastoma cultures[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3037140-66-9
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Molecular Weight 417.45
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Formula C23H25F2NO4
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SMILES
OCC(C(C=C1)=C(O2)C=C1OCC3=CC=C(CN(C)CCCC(F)F)C=C3)=CC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dual AChE-MAO B-IN-1 Related Classifications
HY-145695 Related Classifications
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