8-Bromo-cAMP sodium salt
Based on 39 publication(s) in Google Scholar
8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 76939-46-3
- Formula: C10H10BrN5NaO6P
- Molecular Weight:430.08
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) 8-Bromo-cAMP sodium salt
More- Nat Commun. 2026 Jun 11. [Abstract]
- J Adv Res. 2026 Feb 19:S2090-1232(26)00162-1. [Abstract]
- Sci Immunol. 2026 May;11(119):eadz0348. [Abstract]
- Adv Sci (Weinh). 2025 Dec 22:e15246. [Abstract]
- Mater Today Bio. 2026 Mar 10:37:103021. [Abstract]
- J Hazard Mater. 2024 Aug 15:475:134854. [Abstract]
- Part Fibre Toxicol. 2022 Feb 17;19(1):13. [Abstract]
- Environ Health (Wash). 2024 Aug 16;2(11):776-785. [Abstract]
- EMBO J. 2024 Nov;43(21):5018-5036. [Abstract]
- Hum Reprod. 2021 Jan 1;36(1):145-159. [Abstract]
- Biochem Pharmacol. 2025 Oct:240:117060. [Abstract]
- Cell Mol Life Sci. 2022 Nov 13;79(12):589. [Abstract]
- Commun Biol. 2025 Jul 4;8(1):995. [Abstract]
- Reprod Biol Endocrinol. 2022 Sep 22;20(1):142. [Abstract]
- Cell Oncol (Dordr). 2023 Aug;46(4):953-967. [Abstract]
- BMC Biol. 2024 May 3;22(1):104. [Abstract]
- Inflammation. 2022 Dec;45(6):2419-2432. [Abstract]
- Cell Signal. 2024 Dec:124:111438. [Abstract]
- Korean J Pain. 2023 Jul 1;36(3):335-346. [Abstract]
- Chem Res Toxicol. 2025 Jul 21;38(7):1266-1280. [Abstract]
- Development. 2026 Apr 15;153(8):dev205191. [Abstract]
- Andrology. 2025 Jun 16. [Abstract]
- Mol Cell Endocrinol. 2023 Aug 20:574:111952. [Abstract]
- J Proteomics. 2025 May 30:316:105437. [Abstract]
- Theriogenology. 2022 Sep 1:189:118-126. [Abstract]
- J Bone Miner Metab. 2021 Sep;39(5):769-779. [Abstract]
- J Assist Reprod Genet. 2024 Nov;41(11):3189-3200. [Abstract]
- J Assist Reprod Genet. 2024 Jun;41(6):1645-1659. [Abstract]
- Reprod Sci. 2023 Apr;30(4):1281-1290. [Abstract]
- J Mol Histol. 2025 Oct 22;56(6):348. [Abstract]
- Biochem Biophys Res Commun. 2025 Nov 19:790:152919. [Abstract]
- Res Sq. 2026 Feb 2.
- University of Bonn. 2025.
- bioRxiv. 2025 March 25.
- Res Sq. 2024 Sep 09.
- SSRN. 2023 Aug 1.
- Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]
- Research Square Preprint. 2021 Jul
- Research Square Preprint. 2021 Jul.
Customer Validation & Images
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Histological Imaging/Staining
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Flow Cytometry
Biological Activity
PKA[1]
8-Bromo-cAMP (0.1/0.5 mM) sodium salt enhances the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, and 0.1 mM of 8-Bromo-cAMP shows a synergistic effect with Valproic acid (HY-10585) (0.5 mM)[1].
8-Bromo-cAMP (20 μM, 24 and 48 h) sodium salt induces apoptosis in esophageal cancer cell line (Eca-109)[2].
8-Bromo-cAMP (0.5 mM, 2 days) sodium salt induces decidualization of human endometrial stromal cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CT26 tumor mice[4]
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Dosage:60 mg/kg/day
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Administration:i.p., 7 days
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Result:Decreases amounts of primary CRC tumor nodules and liver metastases.
Reduces vasculogenic mimicry (PAS–CD31 staining of colorectal and intestinal tumors).
Inhibits cAMP and VEGF expression, increases expression of PKA in tumor tissues.
Chemical Information
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CAS No. 76939-46-3
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Appearance Solid
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Molecular Weight 430.08
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Formula C10H10BrN5NaO6P
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Color White to off-white
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SMILES
BrC1=NC2=C(N=CN=C2N)N1[C@H](O[C@@](CO3)([H])[C@@]4([H])OP3(O[Na])=O)[C@@H]4O
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Synonyms
8-Br-Camp sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (39)
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Journal Impact Factor
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Most Recent
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Nat Commun
Hypothalamic POMC neurons regulate intestinal glucose absorption via a gut-brain circuit. [Abstract]2026 Jun 11. PMID: 42277019 -
J Adv Res
Synergistic regulation of SLC7A11 and glucose-6-phosphate dehydrogenase in redox homeostasis governs decidualization: a mechanistic insight into adenomyosis-related infertility. [Abstract]2026 Feb 19:S2090-1232(26)00162-1. PMID: 41722688 -
Sci Immunol
2026 May;11(119):eadz0348. PMID: 42066062 -
Adv Sci (Weinh)
Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7-Polarized Microfilament Coordination in Breast Cancer Cells. [Abstract]2025 Dec 22:e15246. PMID: 41431193 -
Mater Today Bio
PKA activation rescues myocardial injury elicited by silica nanoparticles through improving oxidative stress, mitochondrial health, and copper homeostasis. [Abstract]2026 Mar 10:37:103021. PMID: 41890951 -
J Hazard Mater
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead. [Abstract]2024 Aug 15:475:134854. PMID: 38889468 -
Part Fibre Toxicol
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway. [Abstract]2022 Feb 17;19(1):13. PMID: 35177090
8-Bromo-cAMP sodium salt purchased from MedChemExpress. Usage Cited in: Part Fibre Toxicol. 2022 Feb 17;19(1):13. [Abstract]
Leydig cells were incubated with 0.2 mg/mL PS-MPs for 1 h and then cultured in serum-free medium in the presence of 0.1 mM 8-Bromo-cAMP sodium salt (0.1 mM) for another 24 h. The expression of StAR in cells was analyzed by western blotting.
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Environ Health (Wash)
Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F-53B Exposure: The Role of PKA Cytoplasmic Retention. [Abstract]2024 Aug 16;2(11):776-785. PMID: 39568694 -
EMBO J
TNFSF14+ natural killer cells prevent spontaneous abortion by restricting leucine-mediated decidual stromal cell senescence. [Abstract]2024 Nov;43(21):5018-5036. PMID: 39261664
8-Bromo-cAMP sodium salt purchased from MedChemExpress. Usage Cited in: EMBO J. 2024 Nov;43(21):5018-5036. [Abstract]
Human ESC cell line (hESCs) was treated with 8-Bromo-cAMP sodium salt (0.5 mM; 1-8 days) plus MPA (1 μM) for different times, and western blotting assay was used to detect the expression of CDKN2A, CDKN1A, TP53 (indicator of cell senescence) and PRL.
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Hum Reprod
Human endometrial perivascular stem cells exhibit a limited potential to regenerate endometrium after xenotransplantation. [Abstract]2021 Jan 1;36(1):145-159. PMID: 33283858 -
Biochem Pharmacol
miR-29a-3p participates in the pathogenesis of spontaneous abortion by inhibiting trophoblast function targeting COL4A2/COL5A1. [Abstract]2025 Oct:240:117060. PMID: 40562119 -
Cell Mol Life Sci
Identification of the common neurobiological process disturbed in genetic and non-genetic models for autism spectrum disorders. [Abstract]2022 Nov 13;79(12):589. PMID: 36371739 -
Commun Biol
Endometrial stromal Menin supports endometrial receptivity by maintaining homeostasis of WNT signaling pathway through H3K4me3 during WOI. [Abstract]2025 Jul 4;8(1):995. PMID: 40610728 -
Reprod Biol Endocrinol
TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway. [Abstract]2022 Sep 22;20(1):142. PMID: 36138481 -
Cell Oncol (Dordr)
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner. [Abstract]2023 Aug;46(4):953-967. PMID: 36939950 -
BMC Biol
GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion. [Abstract]2024 May 3;22(1):104. PMID: 38702712 -
Inflammation
Null Function of Npr1 Disturbs Immune Response in Colonic Inflammation During Early Postnatal Stage. [Abstract]2022 Dec;45(6):2419-2432. PMID: 35794311
8-Bromo-cAMP sodium salt purchased from MedChemExpress. Usage Cited in: Inflammation. 2022 Dec;45(6):2419-2432. [Abstract]
Histopathological changes in the colon tissue sections from from Npr1−/− mice treated with 8-Bromo-cAMP sodium salt (8-Br-cGMP, 0.1 mM; i.v.; Once daily for 4 weeks) or saline (n = 4).
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Cell Signal
Acyl-CoA long-chain synthetase 1 (ACSL1) protects the endometrium from excess palmitic acid stress during decidualization. [Abstract]2024 Dec:124:111438. PMID: 39343116 -
Korean J Pain
Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats. [Abstract]2023 Jul 1;36(3):335-346. PMID: 37394274 -
Chem Res Toxicol
Halogen Atoms in Bisphenol A Derivatives Enhance the Inhibitory Potency against Human and Rat Placental 3β-Hydroxysteroid Dehydrogenases. [Abstract]2025 Jul 21;38(7):1266-1280. PMID: 40511817 -
Development
The neuropeptide FILa modulates larval settlement and ciliary function in the echiuran worm Urechis unicinctus. [Abstract]2026 Apr 15;153(8):dev205191. PMID: 41958431 -
Andrology
Expression of IL-33 in rodent testes and its role in Leydig cell steroidogenesis and aging. [Abstract]2025 Jun 16. PMID: 40521800 -
Mol Cell Endocrinol
NLRP3 inflammasome-mediated Pyroptosis induce Notch signal activation in endometriosis angiogenesis. [Abstract]2023 Aug 20:574:111952. PMID: 37268099 -
J Proteomics
iTRAQ-based quantitative proteomics reveals dysregulation of fibronectin 1 contributes to impaired endometrial decidualization in recurrent implantation failure. [Abstract]2025 May 30:316:105437. PMID: 40187609 -
Theriogenology
Melatonin inhibits testosterone synthesis in Roosters Leydig cells by regulating lipolysis of lipid droplets. [Abstract]2022 Sep 1:189:118-126. PMID: 35753225 -
J Bone Miner Metab
2021 Sep;39(5):769-779. PMID: 33988757 -
J Assist Reprod Genet
High concentration of estrogen resulted by COH may affect the secretion of pro-angiogenic factors in uNK cells by downregulating the expression of IL-11 in decidual stromal cells. [Abstract]2024 Nov;41(11):3189-3200. PMID: 39276273 -
J Assist Reprod Genet
MiR-135a-5p regulates window of implantation by suppressing pinopodes development and decidualization of endometrial stromal cells. [Abstract]2024 Jun;41(6):1645-1659. PMID: 38512656 -
Reprod Sci
Role of the Glycogen Synthase Kinase 3-Cyclic AMP/Protein Kinase A in the Immobilization of Human Sperm by Tideglusib. [Abstract]2023 Apr;30(4):1281-1290. PMID: 36207578 -
J Mol Histol
Shentong Zhuyu decoction ameliorates postherpetic neuralgia in rats by regulating cAMP/PKA/p-CREB signaling. [Abstract]2025 Oct 22;56(6):348. PMID: 41123684 -
Biochem Biophys Res Commun
PKA-mediated Drp1 Ser637 phosphorylation modulates mitochondrial function in the placenta of gestational diabetes mellitus. [Abstract]2025 Nov 19:790:152919. PMID: 41197405 -
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Sci Total Environ
Silica nanoparticles perturbed mitochondrial dynamics and induced myocardial apoptosis via PKA-DRP1-mitochondrial fission signaling. [Abstract]2022 Oct 10:842:156854. PMID: 35750168
8-Bromo-cAMP sodium salt purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]
8-Bromo-cAMP sodium salt (8-Br-cAMP, 100 μM; 2 h) pretreatment significantly elevated both PKA and p-PKA levels in SiNPs-treated AC16 cells.
8-Bromo-cAMP sodium salt purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]
8-Bromo-cAMP sodium salt (8-Br-cAMP, 100 μM; 2 h) pretreatment significantly reduced apoptosis of AC16 cells induced by SiNPs.
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Solvent & Solubility
DMSO : ≥ 125 mg/mL (290.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (232.51 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (232.51 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41. [Content Brief]
[2]. Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11(41):6538-42. [Content Brief]
[3]. Baek MO, et al. Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization. Exp Mol Med. 2018 Oct 30;50(10):1-11. [Content Brief]
[4]. Wang S, et al. Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. Onco Targets Ther. 2018 Jul 2;11:3765-3774 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.3251 mL | 11.6257 mL | 23.2515 mL | 58.1287 mL |
| 5 mM | 0.4650 mL | 2.3251 mL | 4.6503 mL | 11.6257 mL | |
| 10 mM | 0.2325 mL | 1.1626 mL | 2.3251 mL | 5.8129 mL | |
| 15 mM | 0.1550 mL | 0.7750 mL | 1.5501 mL | 3.8752 mL | |
| 20 mM | 0.1163 mL | 0.5813 mL | 1.1626 mL | 2.9064 mL | |
| 25 mM | 0.0930 mL | 0.4650 mL | 0.9301 mL | 2.3251 mL | |
| 30 mM | 0.0775 mL | 0.3875 mL | 0.7750 mL | 1.9376 mL | |
| 40 mM | 0.0581 mL | 0.2906 mL | 0.5813 mL | 1.4532 mL | |
| 50 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1626 mL | |
| 60 mM | 0.0388 mL | 0.1938 mL | 0.3875 mL | 0.9688 mL | |
| 80 mM | 0.0291 mL | 0.1453 mL | 0.2906 mL | 0.7266 mL | |
| 100 mM | 0.0233 mL | 0.1163 mL | 0.2325 mL | 0.5813 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
8-Bromo-cAMP sodium salt Related Classifications
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