103745-39-7
103745-39-7
Chemical Structure
Fasudil
Synonym(s): HA-1077; AT877
- CAS No.: 103745-39-7
- Formula:C14H17N3O2S
- Molecular Weight:291.37
IUPAC Name: 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline
InChIKey: NGOGFTYYXHNFQH-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O
Biological Activity: Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca2+ channel antagonist and vasodilator[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fasudil | 99.98% | Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca2+ channel antagonist and vasodilator. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-10341RFasudil Hydrochloride (Standard) -
Similarity Score 0.97
HY-10341CFasudil dihydrochloride -
Similarity Score 0.92
HY-100984HA-100 -
Similarity Score 0.92
HY-100984AHA-100 hydrochloride -
Similarity Score 0.91
HY-12880HA-100 dihydrochloride -
Similarity Score 0.90
HY-10341DFasudil mesylate -
Similarity Score 0.84
HY-182519HMN-1180 -
Similarity Score 0.81
HY-126376Iso-H7 dihydrochloride -
Similarity Score 0.81
HY-131900RProtein kinase inhibitor H-7 (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Chen M, et al. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50. [Content Brief]
- [2]. Huang XN, et al. The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cordbarrier following experimental autoimmune encephalomyelitis. J Neuroimmunol. 2011 Oct 28;239(1-2):61-7. [Content Brief]
- [3]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4. [Content Brief]
