HMN-1180
HMN-1180 is a selective, competitive neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 5.4 μM against rat nNOS. HMN-1180 exerts no significant effect on endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). HMN-1180 inhibits nitric oxide production. HMN-1180 can be used for the study of nNOS-related neuronal functional physiology.
For research use only. We do not sell to patients.
- CAS No.: 221134-00-5
- Formula: C15H19N3O2S
- Molecular Weight:305.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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nNOS 5.4 (rat) μM (Ki) |
HMN-1180 acts as a selective, competitive inhibitor of rat neuronal nitric oxide synthase (nNOS) with a Ki of 5.4 μM, does not inhibit eNOS or iNOS at concentrations up to 30 μM, and blocks nNOS-mediated NO production in human neuroblastoma SK-N-MC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 221134-00-5
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Molecular Weight 305.40
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Formula C15H19N3O2S
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SMILES
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HMN-1180 Related Classifications
HY-182519 Related Classifications
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