516-50-7
516-50-7
Chemical Structure
Taurodeoxycholic acid
Synonym(s): Taurodeoxycholate
- CAS No.: 516-50-7
- Formula:C26H45NO6S
- Molecular Weight:499.70
IUPAC Name: 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid
InChIKey: AWDRATDZQPNJFN-VAYUFCLWSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
Biological Activity: Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Taurodeoxycholic acid | 99.09% | Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurodeoxycholic acid (Standard) | 97.03% | Taurodeoxycholic acid (Standard) is the analytical standard of Taurodeoxycholic acid. This product is intended for research and analytical applications. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurodeoxycholic acid-d5 | Taurodeoxycholic acid-d5 is the deuterium labeled Taurodeoxycholic acid (HY-B1899). Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurodeoxycholic acid-d4 | 99.40% | Taurodeoxycholic acid-d4 is the deuterium labeled Taurodeoxycholic acid. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurolithocholic acid | 98.38% | Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Glycodeoxycholic acid | 99.91% | Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurodeoxycholate sodium | 99.91% | Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1β-Hydroxytaurodeoxycholic acid | 1β-Hydroxytaurodeoxycholic acid is a metabolite of Deoxycholic Acid (HY-N0593). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Tauroursodeoxycholate (Standard) | ≥98% | Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurocholic acid | 99.83% | Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurodeoxycholic acid sodium hydrate (Standard) | ≥98% | Taurodeoxycholic acid sodium hydrate (Standard) (Taurodeoxycholate sodium hydrate (Standard)) is the analytical standard of Taurodeoxycholic acid sodium hydrate (HY-B1899A). This product is intended for research and analytical applications. Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Glycodeoxycholic acid monohydrate (Standard) | ≥98% | Glycodeoxycholic acid (monohydrate) (Standard) is the analytical standard of Glycodeoxycholic acid (monohydrate). This product is intended for research and analytical applications. Glycodeoxycholic acid monohydrate is a nuclear receptor ligand. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3α,12α-Dihydroxy-7-oxocholanoyltaurine | 3α,12α-Dihydroxy-7-oxocholanoyltaurine (Compound T1) is a bile acid. 3α,12α-Dihydroxy-7-oxocholanoyltaurine can be isolated from the bile of certain common snake species. 3α,12α-Dihydroxy-7-oxocholanoyltaurine serves as a characteristic bile acid for the Viperidae and Elapidae families. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taurochenodeoxycholic acid | 99.90% | Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Villavicencio-Queijeiro A, et al. The fully-active and structurally-stable form of the mitochondrial ATP synthase of Polytomella sp. is dimeric. J Bioenerg Biomembr. 2009 Feb;41(1):1-13. [Content Brief]
- [2]. Kispal G, et al. Isolation and characterization of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from pig heart inner mitochondrial membrane. J Biol Chem. 1986 Oct 25;261(30):14209-13. [Content Brief]
- [3]. Choi HJ, et al. Evaluation of acute and subacute toxicity of sodium Taurodeoxycholate in rats. Drug Chem Toxicol. 2021 May;44(3):268-276. [Content Brief]
- [9]. Zou Y, et al. Taurodeoxycholate ameliorates DSS-induced colitis in mice. Int Immunopharmacol. 2023 Sep;122:110628. [Content Brief]
- [10]. Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001 Oct;171(2):351-60. [Content Brief]
