Ephrin-A1
Ephrin-A1, the founding member of the ephrin family encoded by EFNA1, is a glycosylphosphatidylinositol (GPI)-anchored membrane ligand that activates EphA-class receptor tyrosine kinases such as EphA1, EphA2 and EphA4. Lacking a transmembrane domain and cytoplasmic tail, it signals mainly through its receptors, although GPI-dependent reverse signaling into the ligand-bearing cell has also been described. Ephrin-A1 is prominently expressed in activated and tumor-associated endothelium, where it contributes to angiogenesis and vascular remodeling, and it guides axon pathfinding during neural development. Because of its selective up-regulation in tumor vasculature, ephrin-A1 and its receptors are being explored as targets for vascular-disrupting and anticancer strategies.
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Ephrin-A1 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
