Ephrin-B1
Ephrin-B1 is a transmembrane B-class ephrin encoded by EFNB1 on the X chromosome. Its cytoplasmic tail contains conserved tyrosine residues and a C-terminal PDZ-binding motif, allowing it to transmit reverse signals into the ligand-bearing cell, a defining difference from the GPI-anchored A-class ephrins. Through bidirectional signaling with EphB receptors, ephrin-B1 governs boundary formation, cell sorting and compartmentalization during embryogenesis, including craniofacial and vascular development. Heterozygous loss-of-function mutations in EFNB1 cause craniofrontonasal syndrome, an X-linked disorder with coronal synostosis, hypertelorism and nail anomalies in which males are paradoxically more severely affected. Ephrin-B1 also regulates bone remodeling and postnatal angiogenesis.
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Ephrin-B1 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
