Iprindole hydrochloride
Iprindole hydrochloride, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole hydrochloride shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole hydrochloride induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression.
For research use only. We do not sell to patients.
- CAS No.: 20432-64-8
- Formula: C19H29ClN2
- Molecular Weight:320.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Iprindole (0.1-10 μM; 8 h) hydrochloride induces the formation of lamellar bodies in L-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Iprindole (10-50 mg/kg; i.p.; single dose) hydrochloride shortens the immobility time in male ICR Swiss mice forced swimming test[2].
Iprindole hydrochloride's (20 mg/kg; i.p.; single dose) activity is reserved by the opiate antagonist Naloxone in male ICR Swiss mice forced swimming test[2].
Iprindole hydrochloride's (10 mg/kg; i.p.; single dose) activity is enhanced by inhibitor of its degradation Bestatin (HY-B0134) or Thiorphan (HY-W013375)) in male ICR Swiss mice forced swimming test[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic cats[1]
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Dosage:1.0 mg/kg; 2.0 mg/kg; 5.0 mg/kg; 20 mg/kg; 40 mg/kg
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Administration:i.p.; single dose
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Result:Did not significantly reduce REM sleep compared to population standards.
Did not significantly affect NREM sleep, wakefulness, or indeterminate periods.
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Animal Model:ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
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Dosage:10 mg/kg; 20 mg/kg; 50 mg/kg
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Administration:i.p.; single dose
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Result:Shortened the immobility time.
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Animal Model:ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
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Dosage:20 mg/kg plus Naloxone (1 mg/kg)
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Administration:i.p.; single dose
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Result:Activity was reserved by the opiate antagonist Naloxone.
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Animal Model:ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
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Dosage:10 mg/kg plus Bestatin or
Thiorphan(10 μg/kg) -
Administration:i.p.; single dose
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Result:Further decreased the immobility time.
Chemical Information
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CAS No. 20432-64-8
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Molecular Weight 320.90
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Formula C19H29ClN2
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SMILES
CN(C)CCCN1C(CCCCCC2)=C2C3=C1C=CC=C3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Baxter BL, et al. Iprindole: an antidepressant which does not block REM sleep. Nature. 1969 Aug 16;223(5207):750-2. [Content Brief]
[2]. de Felipe MC, et al. Antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephalin-degrading peptidases. Eur J Pharmacol. 1989 Jan 10;159(2):175-80. [Content Brief]
[3]. Martin WJ 2nd, et al. Iprindole reverses the lamellar body deficiency of cultured L-2 cells. Possible implications in the reversal of surfactant deficiency. Am J Pathol. 1987 Oct;129(1):34-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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