Iprindole hydrochloride

Cat. No.: HY-12392A: Data Sheet Handling Instructions
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Iprindole hydrochloride, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole hydrochloride shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole hydrochloride induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression.

For research use only. We do not sell to patients.

Iprindole hydrochloride Chemical Structure

CAS No. : 20432-64-8

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Other In-stock Forms of Iprindole hydrochloride:

Iprindole

Other Forms of Iprindole hydrochloride:

Iprindole In-stock

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Iprindole (0.1-10 μM; 8 h) hydrochloride induces the formation of lamellar bodies in L-2 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Iprindole (1-40 mg/kg; i.p.; single dose) hydrochloride does not significantly alter REM sleep, NREM sleep, wakefulness, or indeterminate periods at doses up to 40 mg/kg in healthy cats^[1].
Iprindole (10-50 mg/kg; i.p.; single dose) hydrochloride shortens the immobility time in male ICR Swiss mice forced swimming test^[2].
Iprindole hydrochloride's (20 mg/kg; i.p.; single dose) activity is reserved by the opiate antagonist Naloxone in male ICR Swiss mice forced swimming test^[2].
Iprindole hydrochloride's (10 mg/kg; i.p.; single dose) activity is enhanced by inhibitor of its degradation Bestatin (HY-B0134) or Thiorphan (HY-W013375)) in male ICR Swiss mice forced swimming test^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Domestic cats^[1]
Dosage:	1.0 mg/kg; 2.0 mg/kg; 5.0 mg/kg; 20 mg/kg; 40 mg/kg
Administration:	i.p.; single dose
Result:	Did not significantly reduce REM sleep compared to population standards. Did not significantly affect NREM sleep, wakefulness, or indeterminate periods.

Animal Model:	ICR Swiss mice (male, 20-25 g, forced swimming test)^[2]
Dosage:	10 mg/kg; 20 mg/kg; 50 mg/kg
Administration:	i.p.; single dose
Result:	Shortened the immobility time.

Animal Model:	ICR Swiss mice (male, 20-25 g, forced swimming test)^[2]
Dosage:	20 mg/kg plus Naloxone (1 mg/kg)
Administration:	i.p.; single dose
Result:	Activity was reserved by the opiate antagonist Naloxone.

Animal Model:	ICR Swiss mice (male, 20-25 g, forced swimming test)^[2]
Dosage:	10 mg/kg plus Bestatin or Thiorphan(10 μg/kg)
Administration:	i.p.; single dose
Result:	Further decreased the immobility time.

Molecular Weight

320.90

Formula

C₁₉H₂₉ClN₂

CAS No.

20432-64-8

SMILES

CN(C)CCCN1C(CCCCCC2)=C2C3=C1C=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Baxter BL, et al. Iprindole: an antidepressant which does not block REM sleep. Nature. 1969 Aug 16;223(5207):750-2. [Content Brief]

[2]. de Felipe MC, et al. Antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephalin-degrading peptidases. Eur J Pharmacol. 1989 Jan 10;159(2):175-80. [Content Brief]

[3]. Martin WJ 2nd, et al. Iprindole reverses the lamellar body deficiency of cultured L-2 cells. Possible implications in the reversal of surfactant deficiency. Am J Pathol. 1987 Oct;129(1):34-43. [Content Brief]