Iprindole
Based on 1 Customer Validation
Iprindole, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole induces lamellar body formation but devoid of lamellar bodies. Iprindole can be used for the research of depression.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 5560-72-5
- Formula: C19H28N2
- Molecular Weight:284.44
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Iprindole (0.1-10 μM; 8 h) induces the formation of lamellar bodies in L-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Iprindole (10-50 mg/kg; i.p.; single dose) shortens the immobility time in male ICR Swiss mice forced swimming test[2].
Iprindole's (20 mg/kg; i.p.; single dose) activity is reserved by the opiate antagonist Naloxone in male ICR Swiss mice forced swimming test[2].
Iprindole's (10 mg/kg; i.p.; single dose) activity is enhanced by inhibitor of its degradation Bestatin (HY-B0134) or Thiorphan (HY-W013375)) in male ICR Swiss mice forced swimming test[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5560-72-5
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Appearance Oil
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Molecular Weight 284.44
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Formula C19H28N2
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Color Colorless to light yellow
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SMILES
CN(C)CCCN1C2=C(CCCCCC2)C3=C1C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 120 mg/mL (421.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 3 mg/mL (10.55 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 3 mg/mL (10.55 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (294 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Baxter BL, et al. Iprindole: an antidepressant which does not block REM sleep. Nature. 1969 Aug 16;223(5207):750-2. [Content Brief]
[2]. de Felipe MC, et al. Antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephalin-degrading peptidases. Eur J Pharmacol. 1989 Jan 10;159(2):175-80. [Content Brief]
[3]. Martin WJ 2nd, et al. Iprindole reverses the lamellar body deficiency of cultured L-2 cells. Possible implications in the reversal of surfactant deficiency. Am J Pathol. 1987 Oct;129(1):34-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5157 mL | 17.5784 mL | 35.1568 mL | 87.8920 mL |
| 5 mM | 0.7031 mL | 3.5157 mL | 7.0314 mL | 17.5784 mL | |
| 10 mM | 0.3516 mL | 1.7578 mL | 3.5157 mL | 8.7892 mL | |
| 15 mM | 0.2344 mL | 1.1719 mL | 2.3438 mL | 5.8595 mL | |
| 20 mM | 0.1758 mL | 0.8789 mL | 1.7578 mL | 4.3946 mL | |
| 25 mM | 0.1406 mL | 0.7031 mL | 1.4063 mL | 3.5157 mL | |
| 30 mM | 0.1172 mL | 0.5859 mL | 1.1719 mL | 2.9297 mL | |
| 40 mM | 0.0879 mL | 0.4395 mL | 0.8789 mL | 2.1973 mL | |
| 50 mM | 0.0703 mL | 0.3516 mL | 0.7031 mL | 1.7578 mL | |
| 60 mM | 0.0586 mL | 0.2930 mL | 0.5859 mL | 1.4649 mL | |
| 80 mM | 0.0439 mL | 0.2197 mL | 0.4395 mL | 1.0986 mL | |
| 100 mM | 0.0352 mL | 0.1758 mL | 0.3516 mL | 0.8789 mL |
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