1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

JDTic dihydrochloride 

Cat. No.: HY-10487 Purity: 98.18%
Handling Instructions

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

For research use only. We do not sell to patients.
JDTic dihydrochloride Chemical Structure

JDTic dihydrochloride Chemical Structure

CAS No. : 785835-79-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 201 In-stock
5 mg USD 170 In-stock
10 mg USD 271 In-stock
50 mg USD 1046 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of JDTic dihydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

In Vivo

JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine[1]. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point[2]. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats[3]

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8568 mL 9.2842 mL 18.5684 mL
5 mM 0.3714 mL 1.8568 mL 3.7137 mL
10 mM 0.1857 mL 0.9284 mL 1.8568 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

JDTic is dissolved in a physiological saline solution (0.9% sodium chloride).

Mice: Naive mice are injected s.c. with JDTic (1, 4, 8, or 16 mg/kg) 18 h prior to nicotine (2.5 mg/kg, s.c.). Due to JDTic’s very long duration of action, an 18-h preinjection is chosen for the studies. Antinociception using the tail-flick and hot-plate tests is measured 5 min after nicotine injection or 20 min after morphine (8 mg/kg, s.c.), and changes in body temperature are measured 30 min after injection. To confirm an absence of mu antagonist effects by JDTic in these studies, JDTic (16 mg/kg) is also administered 1, 6, 18, and 24 h before morphine (8 mg/kg, s.c.) in the tail-flick test, and antinociception is measured 20 min after morphine. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O=C([[email protected]@H]1NCC2=C(C=CC(O)=C2)C1)N[[email protected]@H](C(C)C)CN3C[[email protected]](C)[[email protected]](C)(C4=CC=CC(O)=C4)CC3.[H]Cl.[H]Cl

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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JDTic dihydrochloride
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