1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. JDTic dihydrochloride

JDTic dihydrochloride 

Cat. No.: HY-10487 Purity: 99.79%
Handling Instructions

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

For research use only. We do not sell to patients.

JDTic dihydrochloride Chemical Structure

JDTic dihydrochloride Chemical Structure

CAS No. : 785835-79-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 201 In-stock
Estimated Time of Arrival: December 31
5 mg USD 170 In-stock
Estimated Time of Arrival: December 31
10 mg USD 271 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1046 In-stock
Estimated Time of Arrival: December 31
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Other Forms of JDTic dihydrochloride:

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JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

In Vivo

JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine[1]. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point[2]. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats[3]

Clinical Trial
Molecular Weight







O=C([[email protected]@H]1NCC2=C(C=CC(O)=C2)C1)N[[email protected]@H](C(C)C)CN3C[[email protected]](C)[[email protected]](C)(C4=CC=CC(O)=C4)CC3.[H]Cl.[H]Cl


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (185.68 mM; Need ultrasonic)

H2O : 50 mg/mL (92.84 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8568 mL 9.2842 mL 18.5684 mL
5 mM 0.3714 mL 1.8568 mL 3.7137 mL
10 mM 0.1857 mL 0.9284 mL 1.8568 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Mice: Naive mice are injected s.c. with JDTic (1, 4, 8, or 16 mg/kg) 18 h prior to nicotine (2.5 mg/kg, s.c.). Due to JDTic’s very long duration of action, an 18-h preinjection is chosen for the studies. Antinociception using the tail-flick and hot-plate tests is measured 5 min after nicotine injection or 20 min after morphine (8 mg/kg, s.c.), and changes in body temperature are measured 30 min after injection. To confirm an absence of mu antagonist effects by JDTic in these studies, JDTic (16 mg/kg) is also administered 1, 6, 18, and 24 h before morphine (8 mg/kg, s.c.) in the tail-flick test, and antinociception is measured 20 min after morphine.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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