1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

JDTic dihydrochloride 

Cat. No.: HY-10487 Purity: 98.18%
Handling Instructions

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

For research use only. We do not sell to patients.

JDTic dihydrochloride Chemical Structure

JDTic dihydrochloride Chemical Structure

CAS No. : 785835-79-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 201 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 170 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 271 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 1046 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of JDTic dihydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

In Vivo

JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine[1]. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point[2]. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats[3]

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8568 mL 9.2842 mL 18.5684 mL
5 mM 0.3714 mL 1.8568 mL 3.7137 mL
10 mM 0.1857 mL 0.9284 mL 1.8568 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

JDTic is dissolved in a physiological saline solution (0.9% sodium chloride).

Mice: Naive mice are injected s.c. with JDTic (1, 4, 8, or 16 mg/kg) 18 h prior to nicotine (2.5 mg/kg, s.c.). Due to JDTic’s very long duration of action, an 18-h preinjection is chosen for the studies. Antinociception using the tail-flick and hot-plate tests is measured 5 min after nicotine injection or 20 min after morphine (8 mg/kg, s.c.), and changes in body temperature are measured 30 min after injection. To confirm an absence of mu antagonist effects by JDTic in these studies, JDTic (16 mg/kg) is also administered 1, 6, 18, and 24 h before morphine (8 mg/kg, s.c.) in the tail-flick test, and antinociception is measured 20 min after morphine. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

538.55

Formula

C₂₈H₄₁Cl₂N₃O₃

CAS No.

785835-79-2

SMILES

O=C([[email protected]@H]1NCC2=C(C=CC(O)=C2)C1)N[[email protected]@H](C(C)C)CN3C[[email protected]](C)[[email protected]](C)(C4=CC=CC(O)=C4)CC3.[H]Cl.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
JDTic dihydrochloride
Cat. No.:
HY-10487
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