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Cat. No.: HY-163311

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Transketolase-IN-6

Transketolase-IN-6 is a potent transketolase inhibitor and a herbicide. Transketolase-IN-6 inhibits root growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis. Transketolase-IN-6 shows low phytotoxicity to wheat, maize, soybean, and cotton. Transketolase-IN-6 can be used for the research of herbicidal agent development.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₅ClN₆O
Molecular Weight:436.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Transketolase-IN-6 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Transketolase-IN-6 (compound 6bj) (200 mg/L; 7 days) potently inhibits root and stem growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis, with root inhibition rates of 89.5%, 77.2%, and 77.4% respectively^[1].
Transketolase-IN-6 (150 g ai/ha; 7 days) inhibits post-emergence growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis by 80.2%, 75.0%, and 82.3% respectively, with GR₅₀ values ranging from 60.372 to 96.768 g ai/ha^[1].
Transketolase-IN-6 (150-300 g ai/ha) is safe for wheat, maize, soybean, and cotton at 150 g ai/ha (injury <10%) and causes <25% injury at 300 g ai/ha^[1].
Transketolase-IN-6 binds strongly to Arabidopsis thaliana transketolase with a binding free energy of 6.394 kcal/mol via multiple hydrogen bond, π−cation, and π−π T-shaped interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 436.94
Formula C₂₃H₂₅ClN₆O
SMILES

ClC1=C(N2N=CC(C(NCC3=CC=CN=C3)=O)=C2N(CC4CC4)CC5CC5)N=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu S, et al. Design, Synthesis, and Herbicidal Activity of Pyrazole Amide Derivatives as Potential Transketolase Inhibitors. J Agric Food Chem. 2024;72(7):3334-3341. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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