2. Anti-infection
  3. Bacterial
  4. Transketolase-IN-4

Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM.

For research use only. We do not sell to patients.

Transketolase-IN-4 Chemical Structure

Transketolase-IN-4 Chemical Structure

CAS No. : 419547-73-2

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Based on 1 publication(s) in Google Scholar

Transketolase-IN-4 Related Antibodies

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Description

Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].

IC50 & Target

IC50: 3.9 μM (Transketolase)[1]; 114.1 μM (Mycobacterium tuberculosis DXS)[2]
Molecular Weight

335.79

Formula

C19H14ClN3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(CC2=CC=CC=C2)NC3=C(C4=CC=C(C=C4)Cl)C=NN13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (372.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9781 mL 14.8903 mL 29.7805 mL
5 mM 0.5956 mL 2.9781 mL 5.9561 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.59%

COA (255 KB) HNMR (255 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9781 mL 14.8903 mL 29.7805 mL 74.4513 mL
5 mM 0.5956 mL 2.9781 mL 5.9561 mL 14.8903 mL
10 mM 0.2978 mL 1.4890 mL 2.9781 mL 7.4451 mL
15 mM 0.1985 mL 0.9927 mL 1.9854 mL 4.9634 mL
20 mM 0.1489 mL 0.7445 mL 1.4890 mL 3.7226 mL
25 mM 0.1191 mL 0.5956 mL 1.1912 mL 2.9781 mL
30 mM 0.0993 mL 0.4963 mL 0.9927 mL 2.4817 mL
40 mM 0.0745 mL 0.3723 mL 0.7445 mL 1.8613 mL
50 mM 0.0596 mL 0.2978 mL 0.5956 mL 1.4890 mL
60 mM 0.0496 mL 0.2482 mL 0.4963 mL 1.2409 mL
80 mM 0.0372 mL 0.1861 mL 0.3723 mL 0.9306 mL
100 mM 0.0298 mL 0.1489 mL 0.2978 mL 0.7445 mL
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Transketolase-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Transketolase-IN-4419547-73-2BacterialInhibitorinhibitorinhibit

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