Thiamine diphosphate analog 1

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Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease.

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Thiamine diphosphate analog 1 Chemical Structure

CAS No. : 2606-90-8

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Description	Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease^[1]^[2]^[3].
In Vitro	Thiamine diphosphate analog 1 bound to wild-type yeast PDC prevails in its protonated C2 form, with no detectable discrete C2 carbanion intermediate^[1]. Thiamine diphosphate analog 1 C₂ deprotonation rate is accelerated by binding to wild-type yeast PDC, wild-type Z. mobilis PDC, and wild-type TK; pyruvamide activation of wild-type yeast PDC further increases this rate to levels that are not rate-limiting for catalysis^[1]. Thiamine diphosphate (extracted from whole blood samples; detected by in vitro HPLC) analog 1 showed a significant difference in content between the Alzheimer's disease group and the control group^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Thiamine diphosphate analog 1 Related Antibodies
Molecular Weight	303.17
Formula	C₆H₁₁NO₇P₂S
CAS No.	2606-90-8
SMILES	O=P(O)(OP(O)(O)=O)OCCC1=C(C)N=CS1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Kern D, et al. How Thiamine Diphosphate Is Activated in Enzymes. Science. 1997 Jan 3;275(5296):67-70. [2]. Duggleby RG, et al. Domain relationships in thiamine diphosphate-dependent enzymes. Acc Chem Res. 2006;39(8):550-557. [3]. Wang C, et al. High thiamine diphosphate level as a protective factor for Alzheimer's disease. Neurol Res. 2018;40(8):658-665.