Thiamine diphosphate analog 1
Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B1 in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 2606-90-8
- Formula: C6H11NO7P2S
- Molecular Weight:303.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Thiamine diphosphate analog 1 bound to wild-type yeast PDC prevails in its protonated C2 form, with no detectable discrete C2 carbanion intermediate[1].
Thiamine diphosphate analog 1 C2 deprotonation rate is accelerated by binding to wild-type yeast PDC, wild-type Z. mobilis PDC, and wild-type TK; pyruvamide activation of wild-type yeast PDC further increases this rate to levels that are not rate-limiting for catalysis[1].
Thiamine diphosphate (extracted from whole blood samples; detected by in vitro HPLC) analog 1 showed a significant difference in content between the Alzheimer's disease group and the control group[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2606-90-8
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Molecular Weight 303.17
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Formula C6H11NO7P2S
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SMILES
O=P(O)(OP(O)(O)=O)OCCC1=C(C)N=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thiamine diphosphate analog 1 Related Classifications
HY-128606 Related Classifications
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- Thiamine diphosphate analog 1
- 2606-90-8
- Thiamine diphosphate analog1
- Thiamine diphosphate analog-1
- Endogenous Metabolite
- Transketolase
- wild-type TK
- transketolase
- Alzheimer’s disease
- wild-type yeast PDC
- α-ketoglutarate dehydrogenase complex
- yeast PDC E51Q mutant
- pyruvate dehydrogenase complex
- wild-type Z. mobilis PDC
- pyruvate decarboxylase
- TK E418A mutant
- Inhibitor
- inhibitor
- inhibit