2. Recombinant Proteins
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Immunoglobulin-like Cell Adhesion Molecules
  6. Contactin-2
  7. Contactin-2/CNTN2 Protein, Human (HEK293, His)

Contactin-2/CNTN2 Protein, Human (HEK293, His)

Cat. No.: HY-P70054
Handling Instructions

The Contactin-2/CNTN2 protein, together with CNTNAP2, organizes axonal domains at the nodes of Ranvier and maintains voltage-gated potassium channels in the proximal paranodal region. This partnership ensures axonal signaling integrity and function. Contactin-2/CNTN2 Protein, Human (HEK293, His) is the recombinant human-derived Contactin-2/CNTN2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Contactin-2/CNTN2 Protein, Human (HEK293, His) is 982 a.a., with molecular weight of 110-140 kDa.

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Description

The Contactin-2/CNTN2 protein, together with CNTNAP2, organizes axonal domains at the nodes of Ranvier and maintains voltage-gated potassium channels in the proximal paranodal region. This partnership ensures axonal signaling integrity and function. Contactin-2/CNTN2 Protein, Human (HEK293, His) is the recombinant human-derived Contactin-2/CNTN2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Contactin-2/CNTN2 Protein, Human (HEK293, His) is 982 a.a., with molecular weight of 110-140 kDa.
Background

Contactin-2/CNTN2 protein, in collaboration with the transmembrane protein CNTNAP2, plays a pivotal role in the organization of axonal domains at nodes of Ranvier, primarily by ensuring the maintenance of voltage-gated potassium channels at the juxtaparanodal region. This intricate partnership highlights its involvement in the structural integrity and functional organization of axonal signaling. Additionally, Contactin-2/CNTN2 may contribute to cell adhesion, implicating its potential role in mediating interactions between cells. The combined actions of Contactin-2/CNTN2 and CNTNAP2 underscore their significance in establishing and maintaining the precise architecture of nodes of Ranvier, crucial for efficient nerve conduction and cellular adhesion processes.
Species

Human
Source

HEK293
Tag

C-6*His
Accession

Q02246 (S31-N1012)
Gene ID
Molecular Construction
N-term
CNTN2 (S31-N1012)
Accession # Q02246
6*His
C-term
Synonyms
rHuContactin-2/CNTN2, His ; Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; Transient axonal glycoprotein 1; CNTN2; AXT; TAG1; TAX1
AA Sequence

SQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVEN

Molecular Weight

110-140 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Contactin-2/CNTN2 Protein, Human (HEK293, His) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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