CNTN2 - contactin 2 Gene

Homo sapiens

Also known as AXT; TAX; TAX1; FAME5; TAG-1

Gene ID: 6900 | Gene type: protein coding

About CNTN2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,042,949-205,078,289 (from NCBI)

This gene has 33 transcripts (splice variants), 222 orthologues, 36 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 36.2) and testis (RPKM 4.9).

Summary

This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016]

CNTN2 Products(2)

mRNA	Protein	Name
NM_001346083.2	NP_001333012.1	contactin-2 precursor
NM_005076.5	NP_005067.1	contactin-2 precursor

CNTN2 Protein Structure

Ig_2

Ig_3

I-set

fn3

0
200
400
600
800
1040 a.a.

Protein Preferred Names

Protein Names

contactin-2

axonal glycoprotein TAG-1

Recombinant CNTN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70054	Contactin-2/CNTN2 Protein, Human (HEK293, His)	Q02246 (S31-N1012)	≥95%

Related Diseases

Diseases

Alias

Epilepsy, Familial Adult Myoclonic, 5

FAME5	Fcmte5
Cortical Myoclonic Tremor With Epilepsy, Familial, 5	Familial Adult Myoclonic Epilepsy 5
Epilepsy, Myoclonic, Familial Adult, 5	Familial Cortical Myoclonic Tremor And Epilepsy 5
Familial Cortical Myoclonic Tremor With Epilepsy 5	Epilepsy, Myoclonic, Familial Adult, Type 5

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Tropical Spastic Paraparesis

Tropical Spastic Paraplegia	Ham/Tsp
Htlv-Associated Myelopathy	Tropical Spastic Paralysis
Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis	Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis
Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis	Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis	Tsp
Paraparesis Tropical Spastic	Paraparesis, Tropical Spastic

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Myelopathy, Htlv-1-Associated

HAM	Familial Spastic Paraparesis, Htlv-1-Associated
Tropical Spastic Paraparesis

Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia	Atll
Adult T-Cell Leukaemia	Adult T-Cell Leukaemia/Lymphoma
Adult T-Cell Lymphoma	T Cell Leukemia Lymphoma Adult
Leukemia-Lymphoma, Adult T-Cell	Leukemia, T-Cell
Adult T-Cell Lymphoma/Leukemia

Mild Cognitive Impairment

Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential	Bladder Punlmp
Papillary Urothelial Neoplasm Of Low Malignant Potential	Papillary Transitional Cell Neoplasm Of Low Malignant Potential

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Bladder Papillary Transitional Cell Neoplasm

Urinary Bladder Papillary Urothelial Neoplasm

Bladder Papillary Urothelial Neoplasm

Urinary Tract Papillary Transitional Cell Benign Neoplasm

Inverted Papilloma Of Urinary Tract	Papillary Transitional Cell Neoplasm Of The Urinary Tract
Urinary Tract Inverted Papilloma	Inverted Urothelial Papilloma

Tremor

Medicament-Induced Tremor

Medication-Induced Postural Tremor

T-Cell Large Granular Lymphocyte Leukemia

Large Granular Lymphocytic Leukemia	Proliferation Of Large Granular Lymphocytes
T-Lgl	T-Cell Lgl Leukemia
Large Granular Lymphocytic Leukaemia	T-Cell Large Granular Lymphocyte Leukaemia
Large Cell Granular Lymphogenous Leukemia	T-Lgl Leukemia
Leukemia Lymphocytic Large Granular	Leukemia, Large Granular Lymphocytic

Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome	CDFES
PTHSL1	Cdfe Syndrome
Pitt-Hopkins Like Syndrome 1	Pitt-Hopkins-Like Syndrome-1
Cntnap2-Related Developmental And Epileptic Encephalopathy	Cntnap2-Related Dee
Mesh	D006985
Mesh	D008607

T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma	Adult Precursor T Lymphoblastic Leukemia
Atll	T-Cell Adult Acute Lymphoblastic Leukemia

Radiation Cystitis

Irradiation Cystitis

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Chronic Inflammatory Demyelinating Polyneuropathy	Cidp
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma

Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02927	CNTN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CNTN2	VGNC	VGNC:71284
Bos taurus	CNTN2	VGNC	VGNC:27537
Mus musculus	CNTN2	MGD	MGI:104518
Felis catus	CNTN2	VGNC	VGNC:61037
Rattus norvegicus	CNTN2	RGD	RGD:3821
Canis familiaris	CNTN2	VGNC	VGNC:39433
Others	CNTN2	NCBI

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