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  5. Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi)

Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P78179
Handling Instructions

Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is 304 a.a., with molecular weight of 52-70 kDa.

For research use only. We do not sell to patients.

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Description

Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is 304 a.a., with molecular weight of 52-70 kDa.

Background

The Nectin-1 Protein facilitates cell-cell contacts through the formation of homophilic or heterophilic trans-dimers. It is known to engage in heterophilic interactions with Nectin-3 and Nectin-4. Additionally, this protein exhibits neurite outgrowth-promoting activity. In the context of microbial infection, Nectin-1 acts as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV).

Species

Human

Source

HEK293

Tag

C-His;C-Avi

Accession

Q15223 (Q31-T334)

Gene ID
Molecular Construction
N-term
Nectin-1 (Q31-T334)
Accession # Q15223
His-Avi
C-term
Synonyms
CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR
Molecular Weight

52-70 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi)
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HY-P78179
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