Biliary Glycoprotein/CD66a
Biliary glycoprotein (CD66a) is the best-characterized member of the CEACAM family and the product of the CEACAM1 gene. Its ectodomain comprises an N-terminal IgV domain followed by up to three IgC domains; alternative splicing yields GPI-anchored or transmembrane isoforms whose cytoplasmic tails carry ITIM and ITSM motifs that recruit SHP-1 and SHP-2 phosphatases. As biliary glycoprotein it lines the canalicular membrane of hepatocytes and contributes to bile canaliculus structure; on granulocytes CD66a mediates adhesion, activation and clearance of bacteria and is exploited by Opa proteins of Neisseria and by E. coli. CEACAM1 also regulates angiogenesis, insulin signaling and T cell responses, and its dysregulation is linked to metabolic disease and cancer.
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Biliary Glycoprotein/CD66a Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
