1. Recombinant Proteins
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. Biliary Glycoprotein/CD66a
  6. CEACAM1 Protein, Mouse (394a.a, HEK293, His)

CEACAM1 Protein, Mouse (394a.a, HEK293, His)

Cat. No.: HY-P77630
Handling Instructions

The CEACAM1 protein is a cell adhesion molecule that mediates calcium-independent homologous cell adhesion. CEACAM1 negatively regulates neutrophil and platelet function, downregulates the CSF3R-STAT3 pathway, and modulates insulin clearance and lipogenesis. CEACAM1 Protein, Mouse (394a.a, HEK293, His) is the recombinant mouse-derived CEACAM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CEACAM1 Protein, Mouse (394a.a, HEK293, His) is 394 a.a., with molecular weight of 75-110 kDa.

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Description

The CEACAM1 protein is a cell adhesion molecule that mediates calcium-independent homologous cell adhesion. CEACAM1 negatively regulates neutrophil and platelet function, downregulates the CSF3R-STAT3 pathway, and modulates insulin clearance and lipogenesis. CEACAM1 Protein, Mouse (394a.a, HEK293, His) is the recombinant mouse-derived CEACAM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CEACAM1 Protein, Mouse (394a.a, HEK293, His) is 394 a.a., with molecular weight of 75-110 kDa.

Background

CEACAM1 protein, functioning as a cell adhesion molecule, mediates homophilic cell adhesion in a calcium-independent manner. It plays a multifaceted role as a coinhibitory receptor in immune responses and insulin action, while also serving as an activator during angiogenesis. Through phosphorylation- and PTPN6-dependent mechanisms, CEACAM1 suppresses signal transduction of associated receptors, inhibiting T-cell cytotoxicity, proliferation, and cytokine production. Moreover, it regulates autoimmunity and anti-tumor immunity by interacting with HAVCR2. In NK cells, it inhibits KLRK1-mediated cytolysis and negatively regulates IL1B production in neutrophils. CEACAM1 down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R, and it also regulates insulin action by promoting INS clearance and controlling lipogenesis in the liver. Furthermore, it functions as an activator in angiogenesis, promoting blood vessel remodeling and arteriogenesis. CEACAM1 regulates vascular permeability, down-regulates cell growth in response to EGF, inhibits platelet aggregation, negatively regulates osteoclastogenesis, and contributes to the regulation of IgA production and secretion associated with microbiota control and resistance to enteropathogens.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

P31809 (E35-G428)

Gene ID

26365  [NCBI]

Molecular Construction
N-term
CEACAM1 (E35-G428)
Accession # P31809
His
C-term
Synonyms
BGP; BGP1; BGPI; CEACAM1; CD66a
Molecular Weight

75-110 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CEACAM1 Protein, Mouse (394a.a, HEK293, His)
Cat. No.:
HY-P77630
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