CEACAM1 Protein, Mouse (HEK293, His)

CEACAM1 protein, functioning as a cell adhesion molecule, mediates homophilic cell adhesion in a calcium-independent manner. It plays a multifaceted role as a coinhibitory receptor in immune responses and insulin action, while also serving as an activator during angiogenesis. Through phosphorylation- and PTPN6-dependent mechanisms, CEACAM1 suppresses signal transduction of associated receptors, inhibiting T-cell cytotoxicity, proliferation, and cytokine production. Moreover, it regulates autoimmunity and anti-tumor immunity by interacting with HAVCR2. In NK cells, it inhibits KLRK1-mediated cytolysis and negatively regulates IL1B production in neutrophils. CEACAM1 down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R, and it also regulates insulin action by promoting INS clearance and controlling lipogenesis in the liver. Furthermore, it functions as an activator in angiogenesis, promoting blood vessel remodeling and arteriogenesis. CEACAM1 regulates vascular permeability, down-regulates cell growth in response to EGF, inhibits platelet aggregation, negatively regulates osteoclastogenesis, and contributes to the regulation of IgA production and secretion associated with microbiota control and resistance to enteropathogens.