Ceacam1 - CEA cell adhesion molecule 1 Gene

Also Known as Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26365

Summary

Enables several functions, including signaling receptor binding activity; virion binding activity; and virus receptor activity. Involved in several processes, including common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; and negative regulation of macromolecule metabolic process. Acts upstream of or within several processes, including modulation by host of viral process; regulation of T cell activation; and regulation of intracellular signal transduction. Located in cell projection membrane; external side of plasma membrane; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and skeleton. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ceacam1 Products (4)

mRNA Protein Name
NM_001039185.1 NP_001034274.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor
NM_001039186.1 NP_001034275.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor
NM_001039187.1 NP_001034276.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor
NM_011926.2 NP_036056.2 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Toll-like receptor binding IPI
IPI: Inferred from physical interaction
22496641 MGI
enables granulocyte colony-stimulating factor receptor binding IPI
IPI: Inferred from physical interaction
21029969 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15467833 MGI
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
22496641 MGI
Biological Process GO Annotation Evidence References Source
involved in blood vessel development IMP
IMP: Inferred from mutant phenotype
21081647 MGI
involved in cell-cell junction organization IMP
IMP: Inferred from mutant phenotype
23800882 MGI
involved in common myeloid progenitor cell proliferation IMP
IMP: Inferred from mutant phenotype
21029969 MGI
involved in granulocyte colony-stimulating factor signaling pathway IMP
IMP: Inferred from mutant phenotype
21029969 MGI
involved in insulin catabolic process IMP
IMP: Inferred from mutant phenotype
18544705 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
17081782 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
25490771 MGI
acts upstream of or within negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
17081782 MGI
involved in negative regulation of granulocyte differentiation IMP
IMP: Inferred from mutant phenotype
21029969 MGI
involved in negative regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
15467833 MGI
involved in negative regulation of interleukin-1 production IMP
IMP: Inferred from mutant phenotype
22496641 MGI
involved in negative regulation of lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
18544705 MGI
involved in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: Inferred from mutant phenotype
23696226 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
25490771 MGI
involved in negative regulation of platelet aggregation IMP
IMP: Inferred from mutant phenotype
19008452 MGI
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
22496641 MGI
involved in negative regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
21081647 MGI
involved in positive regulation of vasculogenesis IMP
IMP: Inferred from mutant phenotype
22962327 MGI
involved in regulation of blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
16680193 MGI
involved in regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
16680193 MGI
involved in regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
16680193 MGI
involved in regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15467833 MGI
involved in regulation of sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
16680193 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19008452 MGI
located in ciliary membrane IDA
IDA: Inferred from direct assay
22179047 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23123061 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22179047 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carcinoembryonic antigen-related cell adhesion molecule 1

  • BGP-1

  • CEA-related cell adhesion molecule 1

  • MHV-R

  • biliary glycoprotein 1

  • biliary glycoprotein D

  • carcinoembryonic antigen 1

  • carcinoembryonic antigen 7

  • hepatitis virus (MHV-4) susceptibility

  • hepatitis virus receptor

  • murine hepatitis virus receptor

Recombinant Ceacam1 Proteins

Cat. No. Product Name Accession Purity
HY-P75360 CEACAM1 Protein, Mouse (HEK293, Fc) Q925P3/NP_001034274.1 (E35-G428) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P77630 CEACAM1 Protein, Mouse (HEK293, His) P31809-1 (E35-G428) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77632 CLEC5A/MDL-1 Protein, Human (HEK293, Fc) Q9NY25 (Y26-K188) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990569 CM-24 96.02% Phase 2
HY-P991396 LY-3321367 Inhibitor 99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163028 ML-T7 99.93% Unkown
HY-155175 TIM-3-IN-2 99.44% Unkown
HY-159884 MG-T-19 98.34% Unkown
HY-RS02435 CEACAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17387 Ceacam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23842 Ceacam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990821 Anti-Mouse TIM-3 Antibody (RMT3-23) Inhibitor 99.64% Unkown
HY-P990004 Anti-Mouse TIM-3 Antibody (B8.2C12) Inhibitor 99.48% Unkown
HY-P991198 M6903 Ligand 98.81% Unkown
HY-P990364 Anti-CEACAM1/CD66a Antibody Inhibitor / Unkown
HY-P992344 DNP002 Inhibitor / Unkown
HY-P990854 Anti-CEACAM1/3/5/6/8 Antibody (6G5j) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ceacam1 NCBI NCBI:634