2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. DNP002

DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001).

For research use only. We do not sell to patients.

DNP002

DNP002 Chemical Structure

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DNP002 Related Antibodies

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Description

DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

CEACAM6

 

CEACAM1

 

CEACAM5

 

In Vitro

DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM family proteins, and it induces cytotoxic T cell activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DNP002 Related Antibodies
Gene ID

4680  [NCBI]

Accession
Target

CEACAM6/CD66c
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNP002 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNP002DNP 002DNP-002Transmembrane Glycoproteintumor cellstumor microenvironmentCEACAM1advanced solid tumorsCEACAM5CEACAM6tumor-associated neutrophilsMDSCscytotoxic T cellsInhibitorinhibitorinhibit

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DNP002
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