ML-T7

Name: ML-T7
Brand: MedChemExpress
SKU: HY-163028
Rating: 4.5 (0 reviews)

Cat. No.: HY-163028 Purity: 99.93%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

ML-T7 화학구조

CAS No. : 459789-75-4

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

ML-T7(10 μM, 0-6 days) enhances TCR/STAT5 signaling and promotes CD8⁺ cell antitumor activity through Tim-3^[1].
ML-T7(10 μM, 24 h) promotes DC maturation and function through Tim-3 and Tim-4, enhances DC antigen-presenting ability^[1].
ML-T7(10 μM, 24 h) enhances CTL activation and cytokine production, decreases apoptosis of CTLs^[1].
ML-T7(10 μM, 48 h) significantly enhances the production of IFN-γ, TNF-α, CD107a, and granzyme B in human NK cell line NK92 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	CD8⁺ cell
Concentration:	10 μM
Incubation Time:	0-6 days
Result:	Increased the phosphorylation of phospholipase C–γ1(PLC-γ1), ZAP70, LCK, ERK1/2, and STAT5 upon anti-CD3/CD28 stimulation.

Cell Invasion Assay^[1]

Cell Line:	Bone Marrow Cells
Concentration:	10 μM
Incubation Time:	24 h
Result:	Increased the expression of DC maturation markers.

In Vivo

ML-T7 (10-50 mg/kg; Intraperitoneal injection; every 2 days, 10 times) inhibits the growth of tumor and prolongs survival of HCC mice, without adverse effects on mice body weight^[1].
ML-T7 (20 mg/kg; Intraperitoneal injection; every 2 days, 10 times) synergizes with Nivolumab (HY-P9903A) to improve the antitumor efficacy of Nivolumab (HY-P9903A) antibodies, and effectively improves HCC mice survival^[1].
ML-T7 (50 mg/kg, Intraperitoneal injection; every 2 days for 3 weeks)shows a good safety profile in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	10-week-old mice with spontaneous orthotopic HCC^[1]
Dosage:	10-50 mg/kg
Administration:	Intraperitoneal injection (i.p.), every 2 days, 10 times
Result:	Increased CD8⁺ T cells in both tumor and spleen. Inhibited T cell exhaustion. Promoted the function of CTLs, NK cells, and DCs.

Animal Model:	10-week-old mice with orthotopic Akt/c-Myc HCC^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection (i.p.), every 2 days, 10 times
Result:	Indicated stronger antituomr activity when treated with ML-T7 and Nivolumab (HY-P9903A). Rejuvenated NK cells by the combination therapy. Inhibited the accumulation of MDSCs and Tregs.

분자량

506.33

화학식

C₂₇H₁₇Cl₂NO₅

CAS No.

459789-75-4

Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=C(C(C13OC(C4C(N(C5=CC=C(C=C5Cl)Cl)C(C43)=O)=O)C6=CC=C(C)C=C6)=O)C=CC=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 66.67 mg/mL (131.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9750 mL	9.8750 mL	19.7500 mL
5 mM	0.3950 mL	1.9750 mL	3.9500 mL
10 mM	0.1975 mL	0.9875 mL	1.9750 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.93%

Select Batch:

Data Sheet (285 KB) SDS (251 KB)

COA (263 KB) HNMR (260 KB) RP-HPLC (260 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Ma S, et al. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci Transl Med. 2023 Nov 15;15(722):eadg6752. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9750 mL	9.8750 mL	19.7500 mL	49.3749 mL
	5 mM	0.3950 mL	1.9750 mL	3.9500 mL	9.8750 mL
	10 mM	0.1975 mL	0.9875 mL	1.9750 mL	4.9375 mL
	15 mM	0.1317 mL	0.6583 mL	1.3167 mL	3.2917 mL
	20 mM	0.0987 mL	0.4937 mL	0.9875 mL	2.4687 mL
	25 mM	0.0790 mL	0.3950 mL	0.7900 mL	1.9750 mL
	30 mM	0.0658 mL	0.3292 mL	0.6583 mL	1.6458 mL
	40 mM	0.0494 mL	0.2469 mL	0.4937 mL	1.2344 mL
	50 mM	0.0395 mL	0.1975 mL	0.3950 mL	0.9875 mL
	60 mM	0.0329 mL	0.1646 mL	0.3292 mL	0.8229 mL
	80 mM	0.0247 mL	0.1234 mL	0.2469 mL	0.6172 mL
	100 mM	0.0197 mL	0.0987 mL	0.1975 mL	0.4937 mL

ML-T7 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML-T7459789-75-4Tim3T-Cell Immunoglobulin and Mucin Containing Protein-3CD366Tim-3 inhibitorTumor ImmunotherapyPtdSerCEACAM1AntitumorInhibitorinhibitorinhibit

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ML-T7

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ML-T7 Related Antibodies

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Biological Activity

순도&문서

References

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ML-T7 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

ML-T7 Related Classifications

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SAFETY DATA SHEET (SDS)

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