CEACAM1 - CEA cell adhesion molecule 1 Gene

Also Known as BGP; BGP1; BGPI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 634

About CEACAM1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,507,306-42,528,481 (from NCBI)

This gene has 15 transcripts (splice variants), 570 orthologues and 24 paralogues. Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues.

Summary

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to Other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, Apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

CEACAM1 Products (6)

mRNA	Protein	Name
NM_001024912.3	NP_001020083.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor
NM_001184813.2	NP_001171742.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor
NM_001184815.2	NP_001171744.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor
NM_001184816.2	NP_001171745.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor
NM_001205344.2	NP_001192273.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor
NM_001712.5	NP_001703.2	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IPI IPI: Inferred from physical interaction	17192268	GOA
enables filamin binding	IPI IPI: Inferred from physical interaction	16291724	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	26483485	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19948502	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	7478590	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11035932	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	18424730	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18424730	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	18424730	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	18424730	GOA
involved in negative regulation of cytotoxic T cell degranulation	IDA IDA: Inferred from direct assay	18424730	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: Inferred from mutant phenotype	23696226	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	16291724	GOA
involved in wound healing, spreading of cells	IDA IDA: Inferred from direct assay	16291724	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	18424730	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10436421	GOA
located in cell junction	IDA IDA: Inferred from direct assay	8018919	GOA
located in cell surface	IDA IDA: Inferred from direct assay	25363763	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	16291724	GOA
located in membrane	IDA IDA: Inferred from direct assay	11994468	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17192268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM1 Protein Structure

V-set

Ig_3

Ig_2

0
100
200
300
400
500
526 a.a.

Protein Preferred Names	Protein Names
carcinoembryonic antigen-related cell adhesion molecule 1	CD66a antigen

CEACAM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CEACAM1	P13688	opaH	Neisseria gonorrhoeae	Q04884	FPS	27442026
Intra	CEACAM1	P13688	opaD	Neisseria gonorrhoeae	Q04883	FPS	27442026
Intra	CEACAM1	P13688	CEACAM1	Homo sapiens	P13688	Protein Array	21982860
Intra	CEACAM1	P13688	CEACAM1	Homo sapiens	P13688	FPS	27442026
Cross	CEACAM1	P13688	uspa1	Moraxella catarrhalis	Q8GH87	SAXS	18497748
Cross	CEACAM1	P13688	uspa1	Moraxella catarrhalis	Q8GH87	Far-WB	18497748
Cross	CEACAM1	P13688	uspa1	Moraxella catarrhalis	Q8GH87	ITC	18497748
Cross	CEACAM1	P13688	uspa1	Moraxella catarrhalis	Q8GH87	ELISA	18497748
Intra	CEACAM1	P13688	CEACAM1	Homo sapiens	P13688	Solution Sedimentation	26483485
Intra	CEACAM1	P13688	CEACAM6	Homo sapiens	P40199	Protein Array	21982860
Intra	CEACAM1	P13688	CARTPT	Homo sapiens	Q16568	SPR	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72128	CEACAM1 Protein, Human (His-SUMO)	P13688-1 (Q35-G428)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72129	CEACAM1 Protein, Human	P13688-1 (Q35-G428)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72695	CEACAM1 Protein, Human (HEK293, His)	P13688-1 (Q35-G428)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72932	CEACAM1 Protein, Human (HEK293, His-Fc)	P13688-1 (Q35-G428)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78894	CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi)	P13688-1 (Q35-G428)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72129A	CEACAM1 Protein, Human (N-His)	P13688-1 (Q35-G428)	≥ 95%, as determined by reducing SDS-PAGE.

CEACAM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80985	CEACAM1 Antibody (YA3496)	WB, IHC-P, ICC/IF, IP	Human
HY-P84091	CEACAM1 Antibody (YA3788)	WB, IHC-P, FC, ELISA	Human
HY-P84091A	CEACAM1 Antibody (YA3788)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Acute Gonococcal Endometritis	Gonococcal Endometritis Acute Gonorrhea Of Uterus Uterus - Acute Gonorrhoea
Adenomatoid Tumor	Adenomatoid Tumour Benign Localised Epithelial Mesothelioma Benign Localized Epithelial Mesothelioma
Acute Cervicitis
Acute Gonococcal Cervicitis	Gonococcal Cervicitis Acute Gonorrhea Of Cervix
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastrointestinal Carcinoma	Gastrointestinal Neoplasms
Chronic Gonococcal Salpingitis	Gonococcal Salpingitis
Fallopian Tube Disease	Fallopian Tube Diseases
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Salpingitis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163028	ML-T7		99.93%	Unkown
HY-155175	TIM-3-IN-2		99.44%	Unkown
HY-159884	MG-T-19		98.34%	Unkown
HY-RS02435	CEACAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17387	Ceacam1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23842	Ceacam1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990821	Anti-Mouse TIM-3 Antibody (RMT3-23)	Inhibitor	99.64%	Unkown
HY-P990004	Anti-Mouse TIM-3 Antibody (B8.2C12)	Inhibitor	99.48%	Unkown
HY-P991198	M6903	Ligand	98.81%	Unkown
HY-P991396	LY-3321367	Inhibitor	99.0%	Unkown
HY-P990364	Anti-CEACAM1/CD66a Antibody	Inhibitor	/	Unkown
HY-P992344	DNP002	Inhibitor	/	Unkown
HY-P990854	Anti-CEACAM1/3/5/6/8 Antibody (6G5j)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CEACAM1	RGD	RGD:67396
Others	CEACAM1	NCBI