CEACAM1 - CEA cell adhesion molecule 1 Gene

Homo sapiens

Also known as BGP; BGP1; BGPI

Gene ID: 634 | Gene type: protein coding

About CEACAM1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,507,306-42,528,481 (from NCBI)

This gene has 15 transcripts (splice variants), 570 orthologues and 24 paralogues. Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues.

Summary

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, Apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

CEACAM1 Products(6)

mRNA	Protein	Name
NM_001024912.3	NP_001020083.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor
NM_001184813.2	NP_001171742.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor
NM_001184815.2	NP_001171744.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor
NM_001184816.2	NP_001171745.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor
NM_001205344.2	NP_001192273.1	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor
NM_001712.5	NP_001703.2	carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

CEACAM1 Protein Structure

V-set

Ig_3

Ig_2

0
100
200
300
400
526 a.a.

Protein Preferred Names

Protein Names

carcinoembryonic antigen-related cell adhesion molecule 1

CD66a antigen

Recombinant CEACAM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72128	CEACAM1 Protein, Human (His-SUMO)	P13688 (Q35-G428)	≥95%
HY-P72129	CEACAM1 Protein, Human	P13688 (Q35-G428)	≥95%
HY-P72695	CEACAM1 Protein, Human (HEK293, His)	P13688 (Q35-G428)	≥95%
HY-P73508	CEACAM1 Protein, Human (428a.a, HEK293, His)	P13688 (M1-G428)	≥95%
HY-P72932	CEACAM1 Protein, Human (HEK293, His-Fc)	P13688 (Q35-G428)	≥95%
HY-P78894	CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi)	P13688 (Q35-G428)	≥95%
HY-P72129A	CEACAM1 Protein, Human (N-His)	P13688 (Q35-G428)	≥95%

Related Diseases

Diseases

Alias

Acute Gonococcal Endometritis

Gonococcal Endometritis	Acute Gonorrhea Of Uterus
Uterus - Acute Gonorrhoea

Adenomatoid Tumor

Adenomatoid Tumour	Benign Localised Epithelial Mesothelioma
Benign Localized Epithelial Mesothelioma

Acute Cervicitis

Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Gastrointestinal Carcinoma

Gastrointestinal Neoplasms

Chronic Gonococcal Salpingitis

Gonococcal Salpingitis

Fallopian Tube Disease

Fallopian Tube Diseases

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Salpingitis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155175	TIM-3-IN-2	Inhibitor	99.36%	Unkown
HY-163028	ML-T7		99.85%	Unkown
HY-RS02435	CEACAM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CEACAM1	RGD	RGD:67396
Canis familiaris	CEACAM1	NCBI
Mus musculus	CEACAM1	NCBI
Others	CEACAM1	NCBI

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