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M6903

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M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 98.81%
  • Molecular Weight:142 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for M6903
  • Experimental Validation Results for M6903
  • M6903 Chemical Structure
    M6903 Chemical Structure
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609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Immobilized Human TIM-3/HAVCR2 Protein, Mouse IgG2a Fc Tag can bind M6903. The EC50 for this effect is 59.77 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with M6903 (HY-P991198, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • M6903 Chemical Structure
    1/16
  • M6903
  • Immobilized Human TIM-3/HAVCR2 Protein, Mouse IgG2a Fc Tag can bind M6903. The EC50 for this effect is 59.77 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with M6903 (HY-P991198, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).