Contactin-1
Contactin-1 (CNTN1, F3/11) is a GPI-anchored neuronal adhesion molecule built from six immunoglobulin-like and four fibronectin type III domains. It is enriched on axonal membranes and at nodes of Ranvier, where it complexes with contactin-associated protein (Caspr) and neurofascin to organize the paranodal junctions essential for saltatory conduction. Contactin-1 promotes neurite outgrowth and axon fasciculation through interactions with extracellular matrix components and with other IgCAMs. Autoantibodies against contactin-1 occur in a subset of patients with chronic inflammatory demyelinating polyneuropathy, and Cntn1-null mice show paranodal disruption, underscoring its role in peripheral myelination.
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Contactin-1 Recombinant Proteins (2)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
