Contactin-1/CNTN1 Protein, Mouse (HEK293, His)

Contactin-1/CNTN1 protein mediates surface interactions during nervous system development. It forms paranodal axo-glial junctions in peripheral nerves and facilitates axon-glia signaling through CNTNAP1. It acts as a ligand for NOTCH1, promoting NOTCH1 activation. Contactin-1/CNTN1 also interacts with TNR, inhibiting neurite outgrowth. It binds to CNTNAP1 and PTPRZ1, and forms a complex with NRCAM, PTPRB, and TASOR. Contactin-1/CNTN1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Contactin-1/CNTN1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Contactin-1/CNTN1 Protein, Mouse (HEK293, His) is 1000 a.a., with molecular weight of 110-120 kDa.

Contactin-1/CNTN1 protein plays a crucial role in mediating cell surface interactions during nervous system development. It is involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and facilitates signaling between axons and myelinating glial cells through its association with CNTNAP1. This protein also participates in the generation of oligodendrocytes by acting as a ligand for NOTCH1. The interaction between Contactin-1/CNTN1 and NOTCH1 promotes the activation of NOTCH1 through the release of the notch intracellular domain (NICD) and subsequent translocation to the nucleus. Additionally, Contactin-1/CNTN1 interacts with TNR, leading to neuronal repulsion and inhibition of neurite outgrowth. It exists as a monomer and interacts with CNTNAP1 in a cis form, while binding to the carbonic-anhydrase like domain of PTPRZ1. Furthermore, Contactin-1/CNTN1 is detected in a complex with NRCAM and PTPRB and interacts with TASOR.

Mouse

HEK293

C-His

P12960 (M1-L1000)

12805  [NCBI]

110-120 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.