Cntn1 - contactin 1 Gene

Also Known as usl; CNTN; F3cam

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12805

Summary

Enables carbohydrate binding activity. Involved in central nervous system myelin formation and locomotory behavior. Acts upstream of or within several processes, including nervous system development; positive regulation of neuron projection development; and positive regulation of sodium ion transport. Is anchored component of postsynaptic membrane. Is anchored component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; cranial ganglion; genitourinary system; and sensory organ. Used to study Compton-North congenital myopathy. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy. Orthologous to human CNTN1 (contactin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cntn1 Products (5)

mRNA	Protein	Name
NM_001159647.2	NP_001153119.1	contactin-1 precursor
NM_001159648.2	NP_001153120.1	contactin-1 precursor
NM_001358051.2	NP_001344980.1	contactin-1 precursor
NM_001411171.1	NP_001398100.1	contactin-1 precursor
NM_007727.3	NP_031753.1	contactin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	IDA IDA: Inferred from direct assay	19458237	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12700241	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in central nervous system myelin formation	IGI IGI: Inferred from genetic interaction	31641127	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	18354028	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	16029194	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	31641127	MGI
involved in myelination	IGI IGI: Inferred from genetic interaction	31641127	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	31641127	MGI
acts upstream of or within neuron projection development	IGI IGI: Inferred from genetic interaction	19458237	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16029194	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	18354028	MGI
acts upstream of or within positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	16029194	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31171447	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	1729438	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	1729438	MGI
is active in synapse	IDA IDA: Inferred from direct assay	31171447	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
contactin-1	neural cell surface protein F3

Recombinant Cntn1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74224	Contactin-1/CNTN1 Protein, Mouse (HEK293, His)	P12960 (D21-L1000)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02926	CNTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17460	Cntn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23917	Cntn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cntn1	NCBI	NCBI:1272