Nectin-4
Nectin-4, also known as poliovirus receptor-related 4 (PVRL4), is an Ig-like cell adhesion protein of the nectin family that localizes to adherens junctions of epithelial cells. Its ectodomain contains three Ig-like domains of the V-C-C type that engage nectin-3 on opposing cells in trans, establishing cadherin-independent adhesive contacts, and its cytoplasmic tail binds afadin to link the junction to the actin cytoskeleton. Nectin-4 functions as the epithelial receptor for measles virus, including vaccine strains. It is markedly overexpressed in urothelial carcinoma, which led to the antibody-drug conjugate enfortumab vedotin, a Nectin-4-directed therapy approved for advanced bladder cancer.
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Nectin-4 Recombinant Proteins (19)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
