Nectin-4 Protein, Mouse (Biotinylated, HEK293, His-Avi)
Nectin-4 Protein participates in cell adhesion, engaging in trans-homophilic interactions with other Nectin-4 molecules and trans-heterophilic interactions, notably with NECTIN1. It can self-associate, with its Ig-like V-type domain interacting with NECTIN1's Ig-like V-type domain and its C-terminus interacting with AFDN. Nectin-4, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived Nectin-4 protein, expressed by HEK293, with N-Avi labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Nectin-4 Protein participates in cell adhesion, engaging in trans-homophilic interactions with other Nectin-4 molecules and trans-heterophilic interactions, notably with NECTIN1. It can self-associate, with its Ig-like V-type domain interacting with NECTIN1's Ig-like V-type domain and its C-terminus interacting with AFDN. Nectin-4, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived Nectin-4 protein, expressed by HEK293, with N-Avi labeled tag.
Background
The Nectin-4 protein is thought to play a role in cell adhesion through interactions with other proteins. It can engage in both trans-homophilic interactions, where it interacts with other Nectin-4 molecules, and trans-heterophilic interactions, particularly with NECTIN1. It is also capable of self-associating. The protein's Ig-like V-type domain interacts with the Ig-like V-type domain of NECTIN1, while its C-terminus interacts with AFDN.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-Avi;C-His
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Accession
Q8R007 (G31-S347)
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Gene ID71740
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Molecular Construction
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N-term
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Nectin-4 (G31-S347)
Accession # Q8R007 -
His-Avi
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C-term
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Protein Length
Extracellular Domain
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Conjugation
Biotin
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Synonyms
NECTIN4; Poliovirus Receptor-Related Protein 4; Prev. PVRL4; Poliovirus Receptor-Related 4; Nectin-4; Nectin 4; PRR4; EDSS1; LNIR; Nectin Cell Adhesion Molecule 4; Ig Superfamily Receptor LNIR
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AA Sequence
GELETSDVVTVVLGQDAKLPCFYRGDPDEQVGQVAWARVDPNEGIRELALLHSKYGLHVNPAYEDRVEQPPPPRDPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARMRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTQSSRSFTHPRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDRRITHTLQVAFLAEASVRGLEDQNLWQVGREGATLKCLSEGQPPPKYNWTRLDGPLPSGVRVKGDTLGFPPLTTEHSGVYVCHVSNELSSRDSQVTVEVLDPEDPGKQVDLVSAS
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Predicted Molecular Mass
37.9 kDa
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Molecular Weight
Approximately 43-48 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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