1. Recombinant Proteins
  2. CAR-T Related Proteins Receptor Proteins Biotinylated Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. Nectin-4
  6. Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi)

Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P78181
Handling Instructions

The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-4 protein IgV domain, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi) is 115 a.a., with molecular weight of 16-20 kDa.

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Description

The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-4 protein IgV domain, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi) is 115 a.a., with molecular weight of 16-20 kDa.

Background

The Nectin-4 Protein IgV domain plays a crucial role in cell adhesion, engaging in both trans-homophilic and -heterophilic interactions. Specifically, it forms interactions with NECTIN1, contributing to cellular adhesion processes. However, it does not function as a receptor for alpha-herpesvirus entry into cells. In the context of microbial infection, the Nectin-4 IgV domain acts as a receptor for measles virus, facilitating the entry of the virus into host cells. This highlights the dual role of Nectin-4 in cell adhesion and its significance as a specific receptor for measles virus infection.

Species

Human

Source

HEK293

Tag

C-Avi;C-His

Accession

Q96NY8 (G32-L146)

Gene ID
Molecular Construction
N-term
Nectin-4 (G32-L146)
Accession # Q96NY8
His-Avi
C-term
Synonyms
EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4
Molecular Weight

16-20 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi)
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HY-P78181
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