NECTIN4 - nectin cell adhesion molecule 4 Gene

Also Known as LNIR; PRR4; EDSS1; PVRL4; nectin-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81607

About NECTIN4

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,070,998-161,089,558 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues, 14 paralogues and is associated with 3 phenotypes. Biased expression in skin (RPKM 30.6), esophagus (RPKM 23.7) and 7 other tissues.

Summary

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

NECTIN4 Products (1)

mRNA	Protein	Name
NM_030916.3	NP_112178.2	nectin-4 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22902367	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECTIN4 Protein Structure

V-set

C2-set_2

0
100
200
300
400
510 a.a.

Protein Preferred Names	Protein Names
nectin-4	Ig superfamily receptor LNIR

NECTIN4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NECTIN4	Q96NY8	NECTIN1	Homo sapiens	Q15223	Protein Array	21982860
Intra	NECTIN4	Q96NY8	NECTIN4	Homo sapiens	Q96NY8	SPR	22902367
Intra	NECTIN4	Q96NY8	NECTIN4	Homo sapiens	Q96NY8	X-Ray Diffraction	22902367
Intra	NECTIN4	Q96NY8	EIF2B3	Homo sapiens	Q9NR50	Anti Tag CoIP	33961781
Intra	NECTIN4	Q96NY8	EIF2B1	Homo sapiens	Q14232	Anti Tag CoIP	33961781
Cross	NECTIN4	Q96NY8	H	measles virus	Q786F2	SPR	22048310
Intra	NECTIN4	Q96NY8	EIF2B3	Homo sapiens	Q9NR50	Anti Tag CoIP	28514442
Intra	NECTIN4	Q96NY8	EIF2B1	Homo sapiens	Q14232	Anti Tag CoIP	28514442
Intra	NECTIN4	Q96NY8	EIF2B2	Homo sapiens	P49770	Anti Tag CoIP	33961781
Intra	NECTIN4	Q96NY8	EIF2B2	Homo sapiens	P49770	Anti Tag CoIP	28514442
Intra	NECTIN4	Q96NY8	NECTIN4	Homo sapiens	Q96NY8	Solution Sedimentation	22902367
Cross	NECTIN4	Q96NY8	H	measles virus	Q786F2	Far-WB	22048310
Intra	NECTIN4	Q96NY8	TIGIT	Homo sapiens	Q495A1	Protein Array	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECTIN4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70616	Nectin-4 Protein, Human (HEK293, His)	Q96NY8-1 (G32-V351)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72401	Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi)	Q96NY8-1 (G32-V351)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78181	Nectin-4 IgV domain Protein, Human (Biotinylated, HEK293, His-Avi)	Q96NY8-1 (G32-L146)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78373	Nectin-4 Protein, Human (HEK293, Fc)	Q96NY8-1 (G32-S349)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78374	Nectin-4 Protein, Human (HEK293, His-Avi)	Q96NY8-1 (G32-V351)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78375	Nectin-4 IgV domain Protein, Human (HEK293, His-Avi)	Q96NY8-1 (G32-L146)	≥ 95%, as determined by Bis-Tris PAGE.

NECTIN4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86995	Nectin-4 Antibody (YA6688)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Ectodermal Dysplasia-Syndactyly Syndrome 1	EDSS1 Ectodermal Dysplasia-Syndactyly Syndrome Edss Dysplasia, Ectodermal, Syndactyly Syndrome, Type 1
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome	Orofacial Cleft 7 Zlotogora-Ogur Syndrome CLPED1 Ectodermal Dysplasia, Margarita Island Type Ed4 Cleft Lip-Palate-Ectodermal Dysplasia Syndrome Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate Ectodermal Dysplasia 4 Ectodermal Dysplasia Margarita Type Ectodermal Dysplasia, Type 4 Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly Margarita Type Of Ectodermal Dysplasia Zlotogora-Zilberman-Tenenbaum Syndrome Ectd4 Ectodermal Dysplasia 4, Hair/Nail Type EDMI Ectodermal Dysplasia Type 4 Margarita Island Ectodermal Dysplasia Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate Non-Syndromic Orofacial Cleft 7 OFC7 Non-Syndromic Cleft Lip/Palate 7 Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Skin Angiosarcoma	Angiosarcoma Of Skin Hemangiosarcoma Of The Skin Haemangiosarcoma Of Skin Lymphangiosarcoma Of Skin Cutaneous Angiosarcoma Malignant Haemangioendothelioma Of Skin
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Testicular Fibroma
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99016A	Enfortumab vedotin-ejfv	Inhibitor	99.69%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99016	Enfortumab	Inhibitor	99.90%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990977	Bulumtatug		≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147271	Mal-PEG8-Val-Ala-PAB-Exatecan	Inhibitor	99.48%	Unkown
HY-178489	BGC1614		/	Unkown
HY-P11837	NECT-224		/	Unkown
HY-RS09177	NECTIN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21247	Nectin4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27764	Nectin4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99016B	Enfortumab vedotin-ejfv (solution)	Inhibitor	99.78%	Unkown
HY-P991707	Notiretatug	Inhibitor	99.90%	Unkown
HY-P991742	LY4101174 Antibody		99.46%	Unkown
HY-P992133	Sutantatug	Inhibitor	99.9%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NECTIN4	VGNC	VGNC:63766
Macaca mulatta	NECTIN4	VGNC	VGNC:106415
Bos taurus	NECTIN4	VGNC	VGNC:55633
Canis familiaris	NECTIN4	VGNC	VGNC:43719
Rattus norvegicus	NECTIN4	RGD	RGD:1559826
Mus musculus	NECTIN4	MGD	MGI:1918990
Others	NECTIN4	NCBI