Mal-PEG8-Val-Ala-PAB-Exatecan

Cat. No.: HY-147271 Purity: 98.75%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research.

For research use only. We do not sell to patients.

Mal-PEG8-Val-Ala-PAB-Exatecan Chemical Structure

CAS No. : 2679821-39-5

Size	Price	Stock	Quantity
5 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1685	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2700	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Protease Cleavable Linker

Molecular Weight

1329.42

Formula

C₅₄H₆₁FN₈O₁₄

CAS No.

2679821-39-5

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O.[7]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (75.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7522 mL	3.7610 mL	7.5221 mL
5 mM	0.1504 mL	0.7522 mL	1.5044 mL
10 mM	0.0752 mL	0.3761 mL	0.7522 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.75%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (249 KB) HNMR (241 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Manel KRAIEM. Treatment of cancer. WO2021151984A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7522 mL	3.7610 mL	7.5221 mL	18.8052 mL
	5 mM	0.1504 mL	0.7522 mL	1.5044 mL	3.7610 mL
	10 mM	0.0752 mL	0.3761 mL	0.7522 mL	1.8805 mL
	15 mM	0.0501 mL	0.2507 mL	0.5015 mL	1.2537 mL
	20 mM	0.0376 mL	0.1881 mL	0.3761 mL	0.9403 mL
	25 mM	0.0301 mL	0.1504 mL	0.3009 mL	0.7522 mL
	30 mM	0.0251 mL	0.1254 mL	0.2507 mL	0.6268 mL
	40 mM	0.0188 mL	0.0940 mL	0.1881 mL	0.4701 mL
	50 mM	0.0150 mL	0.0752 mL	0.1504 mL	0.3761 mL
	60 mM	0.0125 mL	0.0627 mL	0.1254 mL	0.3134 mL