MC-VA-PAB-Exatecan
Based on 1 publication(s) in Google Scholar
MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.88%
- CAS No.: 2680543-57-9
- Formule: C50H54FN7O11
- Masse moléculaire:948.00
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC-VA-PAB-Exatecan
MoreVoir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC
MoreVoir tous les produits spécifiques à Isoform Topoisomerase
More
Activité biologique
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Camptothecins |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2680543-57-9
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Appearance Solid
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Masse moléculaire 948.00
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Formule C50H54FN7O11
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Color Light yellow to yellow
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SMILES
O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
DMF : ≥ 100 mg/mL (105.49 mM)
DMSO : 100 mg/mL (105.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO | 1 mM | 1.0549 mL | 5.2743 mL | 10.5485 mL | 26.3713 mL |
| 5 mM | 0.2110 mL | 1.0549 mL | 2.1097 mL | 5.2743 mL | |
| 10 mM | 0.1055 mL | 0.5274 mL | 1.0549 mL | 2.6371 mL | |
| 15 mM | 0.0703 mL | 0.3516 mL | 0.7032 mL | 1.7581 mL | |
| 20 mM | 0.0527 mL | 0.2637 mL | 0.5274 mL | 1.3186 mL | |
| 25 mM | 0.0422 mL | 0.2110 mL | 0.4219 mL | 1.0549 mL | |
| 30 mM | 0.0352 mL | 0.1758 mL | 0.3516 mL | 0.8790 mL | |
| 40 mM | 0.0264 mL | 0.1319 mL | 0.2637 mL | 0.6593 mL | |
| 50 mM | 0.0211 mL | 0.1055 mL | 0.2110 mL | 0.5274 mL | |
| 60 mM | 0.0176 mL | 0.0879 mL | 0.1758 mL | 0.4395 mL | |
| 80 mM | 0.0132 mL | 0.0659 mL | 0.1319 mL | 0.3296 mL | |
| 100 mM | 0.0105 mL | 0.0527 mL | 0.1055 mL | 0.2637 mL |
MC-VA-PAB-Exatecan Related Classifications
HY-147270 Related Classifications
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