AZ14170133
Based on 1 Customer Validation
AZ14170133 (SG 3932; AZ-0133) is a Drug-Linker Conjugates for ADC. AZ14170133 consists of the ADC cytotoxic payload topoisomerase 1 inhibitor and a linker. AZ14170133 can be used for synthesis of ADC AZD9592 (HY-171124) and AZD 8205 (HY-171689). AZ14170133 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 2495742-34-0
- Formula: C57H77N7O18
- Molecular Weight:1148.26
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
![Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT](https://file.medchemexpress.com/product_pic/hy-148820.gif)
Biological Activity
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Camptothecins |
AZD9592 (HY-171124) is an anti-EGFR/c-MET antibody-drug conjugate (ADC) and can be used for non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) research[1].
AZD8205 (HY-171689) is an antibody-drug conjugate (ADC) targeting B7-H4 and can be used in the study of cancers expressing B7-H4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2495742-34-0
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Appearance Solid
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Molecular Weight 1148.26
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Formula C57H77N7O18
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Color White to yellow
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SMILES
O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN6C(C=CC6=O)=O)=O)=O)=O)=O)=CC7=C1COC([C@]7(O)CC)=O
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Synonyms
SG 3932; AZ-0133
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (87.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8709 mL | 4.3544 mL | 8.7088 mL | 21.7721 mL |
| 5 mM | 0.1742 mL | 0.8709 mL | 1.7418 mL | 4.3544 mL | |
| 10 mM | 0.0871 mL | 0.4354 mL | 0.8709 mL | 2.1772 mL | |
| 15 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4515 mL | |
| 20 mM | 0.0435 mL | 0.2177 mL | 0.4354 mL | 1.0886 mL | |
| 25 mM | 0.0348 mL | 0.1742 mL | 0.3484 mL | 0.8709 mL | |
| 30 mM | 0.0290 mL | 0.1451 mL | 0.2903 mL | 0.7257 mL | |
| 40 mM | 0.0218 mL | 0.1089 mL | 0.2177 mL | 0.5443 mL | |
| 50 mM | 0.0174 mL | 0.0871 mL | 0.1742 mL | 0.4354 mL | |
| 60 mM | 0.0145 mL | 0.0726 mL | 0.1451 mL | 0.3629 mL | |
| 80 mM | 0.0109 mL | 0.0544 mL | 0.1089 mL | 0.2722 mL |
AZ14170133 Related Classifications
HY-145399 Related Classifications
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