Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan

Cat. No.: HY-145399 Purity: 98.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan can be used to synthesis antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.

Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan Chemical Structure

CAS No. : 2495742-34-0

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3450	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5400	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 8600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1148.26

Formula

C₅₇H₇₇N₇O₁₈

CAS No.

2495742-34-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN6C(C=CC6=O)=O)=O)=O)=O)=O)=CC7=C1COC([C@]7(O)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (174.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8709 mL	4.3544 mL	8.7088 mL
5 mM	0.1742 mL	0.8709 mL	1.7418 mL
10 mM	0.0871 mL	0.4354 mL	0.8709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.95%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (255 KB) HNMR (214 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Schmidt, et al. Computer-based scoring method indicating a cancer patient's response to an anti-B7H4 antibody-drug conjugate therapy using a convolutional neural network, WO2022053685, 2022.

[2]. Philip Wilson Howard, et al. Compounds and conjugates thereof. Patent US20200306243A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8709 mL	4.3544 mL	8.7088 mL	21.7721 mL
	5 mM	0.1742 mL	0.8709 mL	1.7418 mL	4.3544 mL
	10 mM	0.0871 mL	0.4354 mL	0.8709 mL	2.1772 mL
	15 mM	0.0581 mL	0.2903 mL	0.5806 mL	1.4515 mL
	20 mM	0.0435 mL	0.2177 mL	0.4354 mL	1.0886 mL
	25 mM	0.0348 mL	0.1742 mL	0.3484 mL	0.8709 mL
	30 mM	0.0290 mL	0.1451 mL	0.2903 mL	0.7257 mL
	40 mM	0.0218 mL	0.1089 mL	0.2177 mL	0.5443 mL
	50 mM	0.0174 mL	0.0871 mL	0.1742 mL	0.4354 mL
	60 mM	0.0145 mL	0.0726 mL	0.1451 mL	0.3629 mL
	80 mM	0.0109 mL	0.0544 mL	0.1089 mL	0.2722 mL
	100 mM	0.0087 mL	0.0435 mL	0.0871 mL	0.2177 mL