Tilatamig samrotecan
Based on 1 Customer Validation
Tilatamig samrotecan (AZD9592) is an anti-EGFR/c-MET antibody-drug conjugate (ADC). Tilatamig samrotecan consists of an anti-EGFR/c-MET antibody with the drug-linker conjugate being AZ14170133 (HY-145399) (a topoisomerase I (TOP1i) inhibitor payload). Tilatamig samrotecan induces multiple DNA damage response pathway markers (like ATM, ATR, γH2AX). Tilatamig samrotecan selectively binds to EGFR and c-MET, delivering the cytotoxic payload. Tilatamig samrotecan exerts anti-tumor activity in vivo. Tilatamig samrotecan can be used for non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) research.
For research use only. We do not sell to patients.
- Purity: 95.26%
- Molecular Weight:151659 (average)
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Storage:
-80°C, protect from light
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Topoisomerase I |
Tilatamig samrotecan (8 mg/kg, once) achieves tumor growth inhibition (TGI) in 73% (16/22) of models, with tumor volume reduction ≥30% from baseline in EGFR-mutant non-small cell lung cancer (NSCLC) models (heterogeneous EGFR and c-MET expression levels, and regardless of prior EGFR tyrosine kinase inhibitor treatment)[1].
Tilatamig samrotecan (8 mg/kg, once) shows TGI in 60% (12/20) and 44% (4/9) of models in PDX models of EGFR wild-type NSCLC and head and neck squamous cell carcinoma (HNSCC), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Liquid
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Molecular Weight 151659 (average)
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Color Colorless to light yellow
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SMILES
[Tilatamig samrotecan]
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Synonyms
AZD9592
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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