MC-GGFG-Exatecan
Based on 6 publication(s) in Google Scholar
MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC).
For research use only. We do not sell to patients.
- CAS No.: 1600418-29-8
- Formula: C49H51FN8O11
- Molecular Weight:946.97
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC-GGFG-Exatecan
MoreAll Drug-Linker Conjugates for ADC Isoforms
MoreAll Topoisomerase Isoforms
More
Biological Activity
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Camptothecins |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1600418-29-8
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Appearance Solid
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Molecular Weight 946.97
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Formula C49H51FN8O11
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Color Light yellow to yellow
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SMILES
O=C1OCC2=C(C=C(C3=NC4=CC(F)=C(C)C(CC[C@@H]5NC(CNC([C@@H](NC(CNC(CNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=C4C5=C3C8)N8C2=O)[C@@]1(O)CC
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Synonyms
MC-GGFG-DX8951
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Cancer Lett
Antibody-drug conjugates targeting SSEA-4 inhibits growth and migration of SSEA-4 positive breast cancer cells. [Abstract]2025 Feb 28:611:217453. PMID: 39798832 -
J Pharm Anal
Synergistic approach to combating triple-negative breast cancer: DDR1-targeted antibody-drug conjugate combined with pembrolizumab. [Abstract]2025 May;15(5):101100. PMID: 40521369 -
Mol Cancer Ther
MTX-13, a Novel PTK7-Directed Antibody-Drug Conjugate with Widened Therapeutic Index Shows Sustained Tumor Regressions for a Broader Spectrum of PTK7-Positive Tumors. [Abstract]2023 Oct 2;22(10):1128-1143. PMID: 37352387 -
Mol Cancer Ther
AMT-562, a Novel HER3-targeting Antibody-Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors. [Abstract]2023 Sep 5;22(9):1013-1027. PMID: 37302522 -
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Solvent & Solubility
DMSO : 50 mg/mL (52.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0560 mL | 5.2800 mL | 10.5600 mL | 26.4000 mL |
| 5 mM | 0.2112 mL | 1.0560 mL | 2.1120 mL | 5.2800 mL | |
| 10 mM | 0.1056 mL | 0.5280 mL | 1.0560 mL | 2.6400 mL | |
| 15 mM | 0.0704 mL | 0.3520 mL | 0.7040 mL | 1.7600 mL | |
| 20 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3200 mL | |
| 25 mM | 0.0422 mL | 0.2112 mL | 0.4224 mL | 1.0560 mL | |
| 30 mM | 0.0352 mL | 0.1760 mL | 0.3520 mL | 0.8800 mL | |
| 40 mM | 0.0264 mL | 0.1320 mL | 0.2640 mL | 0.6600 mL | |
| 50 mM | 0.0211 mL | 0.1056 mL | 0.2112 mL | 0.5280 mL |
MC-GGFG-Exatecan Related Classifications
HY-114233 Related Classifications
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